Antibody Therapeutics,9780849385476

Antibody Therapeutics

by ;
ISBN13: 9780849385476
ISBN10: 0849385474
Format: Hardcover
Pub. Date: 1997-03-01
Publisher(s): CRC Pr I Llc
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Summary

Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.

Table of Contents

PART I. ANTIBODIES AS THERAPEUTICS 3(86)
Chapter 1 Unconjugated Antibodies as Therapeutics
3(30)
M. Clark
Chapter 2 Immunotoxins for Treating Cancer and Autoimmune Disease
33(20)
R.J. Kreitman
I. Pastan
Chapter 3 Antibodies as Carriers for Drugs Radioisotopes
53(20)
G. Yarranton
Chapter 4 Tumor Targeting by Antibody-Drug Conjugates
73(16)
I. Benhar
I. Pastan
PART II. APPLICATION OF ANTIBODY THERAPEUTICS 89(78)
Chapter 5 Therapeutic Antibodies in Infectious Disease
89(30)
W.J. Harris
Chapter 6 Antibody Therapeutics: Application to Autoimmunity
119(18)
L. Chatenoud
Chapter 7 Monoclonal Antibodies in Transplantation
137(30)
M.-L. Alegre
PART III. DEVELOPMENT OF ANTIBODY THERAPEUTICS 167(110)
Chapter 8 Regulatory Issues for the Development of Antibody Therapeutics
167(16)
K.J. Lambert
Chapter 9 Manufacture of Antibodies by Large-Scale Mammalian Cell Culture
183(38)
D.K. Robinson
V. Yabannavar
Y. Deo
Chapter 10 Production of Antibody Domains in Prokaryotes
221(26)
M. Better
P. Gavit
Chapter 11 Emerging Production Systems for Antibody Therapeutics
247(30)
A.J.R. Porter
K.J. Bentley
P.M. Cupit
T.P. Wallace
PART IV. RECOMBINANT ANTIBODIES IN THE CLINIC 277(80)
Chapter 12 Development of Zenapax: A Humanized Anti-Tac Antibody
277(24)
J. Hakimi
D. Mould
T.A. Waldmann
C. Queen
C. Anasetti
S. Light
Chapter 13 Progress with a Reshaped Human Monoclonal Antibody, RSHZ19, for the Prophylaxis and Treatment of Respiratory Syncytial Virus Infection
301(16)
S.B. Dillon
T.G. Porter
Chapter 14 CDP571, An Engineered Antibody to Human Tumor Necrosis Factor
317(24)
S. Stephens
O. Vetterlein
M. Sopwith
Chapter 15 The Therapeutic Potential of a PRIMATIZED, Nondepleting Anti-CD4 (IDEC-CE9.1) Monoclonal Antibody in Rheumatoid Arthritis
341(16)
A.M. Solinger
A. Truneh
J.A. Lipani
R.A. Newman
INDEX 357

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