Contributors |
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vii | |
Foreword |
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xi | |
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Preface |
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xv | |
I. GENETICS AND REGULATION |
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1 | (66) |
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3 | (22) |
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Regulation of Bacterial Toxin Synthesis by Iron |
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25 | (14) |
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AraC Family Regulators and Transcriptional Control of Bacterial Virulence Determinants |
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39 | (16) |
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55 | (12) |
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II. TOXIN BIOGENESIS: CROSSING BACTERIAL MEMBRANE BARRIERS |
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67 | (62) |
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Type V Export Systems: Proteins That Export Themselves |
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The Type I Export Mechanism |
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71 | (10) |
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Toxins and Type II Secretion Systems |
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81 | (14) |
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Type III Secretion Systems |
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95 | (20) |
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Type IV Secretion Systems |
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115 | (14) |
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III. TOXIN DELIVERY INTO EUKARYOTIC CELLS |
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129 | (58) |
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Receptors for Bacterial Toxins |
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131 | (18) |
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Domain Structures of Bacterial Toxins |
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Direct Penetration of Bacterial Toxins across the Plasman Membrane |
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149 | (8) |
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Transport of Toxins across Intracellular Membranes |
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157 | (16) |
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Transcytosis of Bacterial Toxins across Mucosal Barriers |
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173 | (14) |
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IV. TOXIN ACTION |
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187 | (122) |
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Membrane-Damaging Toxins: Pore Formation |
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189 | (14) |
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The Vacuolating Toxin VacA of Helicobacter pylori |
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Membrane-Damaging Toxins: Family of RTX Toxins |
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203 | (12) |
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Bacterial Toxins that Covalently Modify Eukaryotic Proteins by ADP-Ribosylation |
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215 | (14) |
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Discovery that the Active Sites of Pseudomonas aeruginosa Exotoxin A and the Heat-Labile Enterotoxin of Escherichia coli Are Superimposable |
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Glucosylating and Deamidating Bacterial Protein Toxins |
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229 | (16) |
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Plant and Bacterial Toxins as RNA N-Glycosidases |
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245 | (12) |
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Cytolethal Distending Toxin |
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257 | (14) |
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271 | (12) |
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Landmarks in Tetanus and Botulinum Research |
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Bacterial Toxins that Modulate Rho GTPase Activity |
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283 | (10) |
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Staphylococcal and Streptococcal Superantigens |
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293 | (16) |
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V. BACTERIAL TOXINS: FRIENDS AND FOES |
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309 | (2) |
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Toxins as Vaccines and Adjuvants |
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311 | (16) |
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Nefarious Uses of Bacterial Toxins |
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327 | |
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Color Plates |
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256 | (79) |
Index |
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335 | |