BRS Biochemistry, Molecular Biology, and Genetics
by Swanson, Todd A.; Kim, Sandra I.; Glucksman, Marc J.Edition: 5th
Format: Paperback
Pub. Date: 2009-12-07
Publisher(s): LWW
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Summary
Thoroughly updated for its Fifth Edition, this popular review book is an excellent aid for USMLE Step 1 preparation and for coursework in biochemistry, molecular biology, and genetics. Chapters are written in an outline format and include pedagogical features such as bolded key words, figures, tables, algorithms, and highlighted clinical correlates. USMLE-style questions and answers follow each chapter and a comprehensive exam appears at the end of the book. A companion website includes an interactive question bank with questions from the book and the fully searchable text.
Table of Contents
| Preface | p. v |
| Publisher's Preface | p. vii |
| Acknowledgments | p. ix |
| Introduction: Organic Chemistry Review | p. 1 |
| Brief Review of Organic Chemistry | p. 1 |
| Acids, Bases, and Buffers | p. 1 |
| Carbohydrate Structure | p. 4 |
| Proteoglycans, Glycoproteins, and Glycolipids | p. 9 |
| Amino Acids | p. 11 |
| Lipids | p. 14 |
| Membranes | p. 16 |
| Nucleotides | p. 18 |
| Review Test | p. 19 |
| Protein Structure and Function | p. 23 |
| General Aspects of Protein Structure | p. 23 |
| Examples of Medically Important Proteins | p. 28 |
| Review Test | p. 34 |
| Enzymes | p. 38 |
| General Properties of Enzymes | p. 38 |
| Dependence of Velocity on Enzyme and Substrate Concentrations, Temperature, and pH | p. 39 |
| The Michaelis-Menten Equation | p. 40 |
| The Lineweaver-Burk Plot | p. 41 |
| Inhibitors | p. 41 |
| Allosteric Enzymes | p. 43 |
| Regulation of Enzyme Activity by Post-Translational (Covalent) Modification | p. 44 |
| Regulation by Protein-Protein Interactions | p. 44 |
| Isoenzymes | p. 45 |
| Review Test | p. 46 |
| Biochemistry of Digestion | p. 50 |
| Digestion of Carbohydrates | p. 50 |
| Digestion of Dietary Triacylglycerol | p. 51 |
| Protein Digestion and Amino Acid Absorption | p. 54 |
| Review Test | p. 57 |
| Glycolysis | p. 63 |
| General Overview | p. 63 |
| Transport of Gulcose into cells | p. 63 |
| Reaction of Glycolysis | p. 64 |
| Special Reactions in Red Blood Cells | p. 66 |
| Regulatory Enzymes of Glycolysis | p. 66 |
| The Fate of Pyruvate | p. 68 |
| Generation of Adenosine Triphosphate by Glycolysis | p. 69 |
| Review Test | p. 72 |
| The Tricarboxylic Acid Cycle, Electron Transport Chain, and Oxidative Metabolism | p. 77 |
| The Tricarboxylic Acid Cycle | p. 77 |
| Electron Transport Chain and Oxidative Phosphorylation | p. 85 |
| Reactive Oxygen Species | p. 90 |
| Review Test | p. 93 |
| Glycogen Metabolism | p. 97 |
| Overview of Glycogen Structure and Metabolism | p. 97 |
| Glycogen Structure | p. 97 |
| Glycogen Synthesis | p. 97 |
| Glycogen Degradation | p. 100 |
| Lysosomal Degradation of Glycogen | p. 101 |
| Regulation of Glycogen Degradation | p. 102 |
| Regulation of Glycogen Synthesis | p. 104 |
| Review Test | p. 105 |
| Gluconeogenesis and the Maintenance of Blood Glucose Levels | p. 109 |
| Overview | p. 109 |
| Reactions of Gluconeogenesis | p. 109 |
| Maintenance of Blood Glucose Levels | p. 114 |
| Review Test | p. 119 |
| Miscellaneous Carbohydrate Metabolism | p. 123 |
| Fructose and Galactose Metabolism | p. 123 |
| Pentose Phosphate Pathway | p. 126 |
| Proteoglycans, Glycoproteins, and Glycolipids | p. 129 |
| Review Test | p. 133 |
| Fatty Acid Metabolism | p. 137 |
| Fatty Acid and Triacylglycerol Synthesis | p. 137 |
| Formation of Triacylglycerol Stores in Adipose Tissue | p. 141 |
| Fatty Acid Oxidation | p. 142 |
| High Yield Comparison from Fatty Acid Synthesis and Oxidation | p. 146 |
| Review Test | p. 147 |
| Cholesterol Metabolism and Blood Lipoproteins | p. 151 |
| Cholesterol and Bile Salt Metabolism | p. 151 |
| Blood Lipoproteins | p. 155 |
| Review Test | p. 159 |
| Ketones and Other Lipid Derivatives | p. 163 |
| Ketone Body Synthesis and Utilization | p. 163 |
| Phospholipid and Sphingolipid Metabolism | p. 165 |
| Metabolism of the Eicosanoids | p. 166 |
| Synthesis of the Steroid Hormones | p. 169 |
| Review Test | p. 172 |
| Amino Acid Metabolism | p. 176 |
| Addition and Removal of Amino Acid Nitrogen | p. 176 |
| Urea Cycle | p. 177 |
| Synthesis and Degradation of Amino Acids | p. 180 |
| Review Test | p. 187 |
| Products Derived From Amino Acids | p. 191 |
| Special Products Derived from Amino Acids | p. 191 |
| Tetrahydrofolate and S-Adenosylmethionine: The One-Carbon Carriers | p. 198 |
| Review Test | p. 201 |
| Nucleotide and Porphyrin Metabolism | p. 203 |
| Purine and Pyrimidine Metabolism | p. 203 |
| Heme Metabolism | p. 208 |
| Review Test | p. 211 |
| Integrative Metabolism and Nutrition | p. 215 |
| Metabolic Fuels and Dietary Requirements | p. 215 |
| Metabolism During the Fed or Absorptive State | p. 219 |
| Fasting | p. 221 |
| Prolonged Fasting (Starvation) | p. 224 |
| Biochemical Functions of Tissues | p. 225 |
| Review Test | p. 229 |
| Molecular Endocrinology | p. 233 |
| General Mechanisms of Hormone Action | p. 233 |
| Regulation of Hormone Levels | p. 236 |
| Actions of Specific Hormones | p. 237 |
| Review Test | p. 247 |
| DNA Replication and Transcription | p. 251 |
| Nucleic Acid Structure | p. 251 |
| Synthesis of DNA (Replication) | p. 256 |
| Synthesis of RNA (Transcription) | p. 262 |
| Review Test | p. 267 |
| RNA Translation and Protein Synthesis | p. 271 |
| Protein Synthesis (Translation of Messenger RNA) | p. 271 |
| Regulation of Protein Synthesis | p. 276 |
| Review Test | p. 282 |
| Genetics | p. 286 |
| Chromosomes | p. 286 |
| Cell Cycle | p. 286 |
| Control of the Cell Cycle | p. 288 |
| Meiosis | p. 289 |
| Gene Dosage | p. 292 |
| Fundamentals of Mendelian Genetics | p. 293 |
| The Punnett Square | p. 294 |
| Modes of Inheritance | p. 294 |
| Moderators of Inheritance | p. 296 |
| Hardy-Weinberg Principle | p. 296 |
| Genetic Testing | p. 297 |
| Review Test | p. 300 |
| Biochemistry of Cancer | p. 305 |
| Oncogenes | p. 305 |
| Tumor-Suppressor Genes | p. 307 |
| Apoptosis | p. 308 |
| Mechanism of Oncogenesis | p. 309 |
| Molecular Carcinogenesis | p. 311 |
| DNA Repair and Carcinogenesis | p. 313 |
| Molecular Progression of Cancer | p. 314 |
| Molecular Markers in Cancer Biology | p. 315 |
| Review Test | p. 316 |
| Techniques in Biochemistry, Molecular Biology, and Genetics | p. 319 |
| Biotechnology Involving Recombinant DNA | p. 319 |
| Technology Involving Proteins | p. 329 |
| Review Test | p. 332 |
| Comprehensive Examination | p. 336 |
| Index | p. 361 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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