| Preface Gowland Hopkins Lecture |
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xvii | |
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Making Methionine: A Love Affair with Folate |
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1 | (8) |
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| 1. Novel Chemistry of Pteridines |
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Structure Elucidations of Dimeric Pteridines |
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9 | (10) |
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A Selective Procedure for 6-Subsituted Pterin Derivatives: Synthesis and Substitution of pterin 6-Triflate |
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19 | (6) |
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Solution and Solid Phase Synthesis of pteridines, Purines and Related Compounds |
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25 | (6) |
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Synthesis of pteridines with C-2 and C-6 Functional Group Diversity |
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31 | (6) |
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Stereospecific Synthesis of 2-Desamino-Tetrahydropterins as Probes of Hydroxylase Cofactor Recognition |
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37 | (6) |
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New Pyranopterin Chemistry Related to Molybdenum and Tungsten Enzymes |
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43 | (6) |
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Application of FDCD Spectroscopy for Determination of Chiralities of Biologically Important Pteridines |
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49 | (6) |
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Photo-Oxidation of Sepiapterin Produces Pterin-6-Carboxylic Acid and H2O2 In Vitro |
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55 | (6) |
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| 2. Pteridine-Dependent Enzymes: Structure, Function and Regulation |
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Regulation of Tyrosine Hydroxylase by S-Glutathiolation: Relevance to Conditions Associated with Dopamine Neuronal Damage |
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61 | (6) |
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The Conformation of Tetrahydro-Biopterin Free and Bound to Aromatic Amino Acid Hydroxylases and NOS |
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67 | (6) |
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Regulatory Properties of the Tetrahydropterin Cofactor in the Reaction Catalyzed by Human Tyrosine Hydroxylase Isoforms 1-4 |
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73 | (6) |
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Structure and Regulation of Phenylalanine Hydroxylase and Implications for Related Enzymes |
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79 | (6) |
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Interaction of Phosphorylated Tyrosine Hydroxylase with 14-3-3 Proteins: Effects on Phosphorylation Kinetics |
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85 | (6) |
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Mechanistic Studies of Tryptophan Hydroxylase |
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91 | (6) |
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Role of Phe313/Trp326 in Determining Substrate Specificity in Tryptophan and Phenylalanine Hydroxylases |
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97 | (6) |
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Possible Contributions of Labile Asparagine Residues to Differences in Regulatory Properties of Human and Rat Phenylalanine Hydroxylase |
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103 | (6) |
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3-(2-Thienyl)-L-Alanine as a Competitive Substrate Analogue and Activator of Human Phenylalanine Hydroxylase |
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109 | (6) |
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The N-Terminus of Human Tyrosine Hydroxylase is Responsible for its Association with Phospholipid Bilayers |
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115 | (6) |
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Mechanisms of Tyrosine Hydroxylase Activation by Stress Activated Protein Kinases |
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121 | (6) |
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Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase |
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127 | (6) |
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Mutation of W457 Alters N-Hydroxy-L-Arginine Oxidation by Inducible NO Synthase: A Single Turnover Study |
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133 | (6) |
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Regulation of Rat Hepatic Phenylalanine Hydroxylating System In Vivo |
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139 | (6) |
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| 3. Mechanism and Regulation of Pteridine Biosynthesis |
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Estradiol Modulates GTP Cyclohydrolase I Gene Expression in Brain Catecholaminergic Systems |
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145 | (6) |
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PKC-Mediated Regulation of GTP Cyclohydrolase I in Mast Cells and Renal Mesangial Cells |
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151 | (6) |
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Regulation of GTP Cyclohydrolase I by Estrogen |
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157 | (6) |
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Sexually Dimorphic GTP Cyclohydrolase I Gene Expression is Independent of Sex Hormones |
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163 | (6) |
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Studies on the Reaction Mechanism of GTP Cyclohydrolase I |
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169 | (6) |
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Site-Directed Mutagenesis of Residues in the Active Site of Sepiapterin Reductase |
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175 | (6) |
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Determination of Residues Of Sepiapterin Reductase Phosphorylated by Ca2+/Calmodulin-Dependent Protein Kinase II |
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181 | (6) |
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The Interaction of GTP Cyclohydrolase I and GTP Cyclohydrolase Feedback Regulatory Protein Can be Detected Using the Yeast TWO-Hybrid System |
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187 | (6) |
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Co-Induction of Tetrahydrobiopterin and Catecholamine Syntheses in V-1-Overexpressing PC12D Cells |
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193 | (6) |
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Sepiapterin Administration Raises Tissue BH4 Levels More Efficiently than BH4 Supplement in Normal Mice |
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199 | (6) |
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Cells Take up BH4, Oxidize it, and the Oxidized Biopterin is Preferentially Released |
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205 | (6) |
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| 4. Pterins in Non-Mammalian Systems |
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Catecholamines-Up, a Negative Regulator of Tyrosine Hydroxylase and GTP Cyclohydrolase I in Drosophila Melanogaster |
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211 | (6) |
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The Pteridine Pathway in the Zebrafish, Danio Rerio: Development in Neural Crest-Derived Cells and its Control by GTP Cyclohydrolase I |
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217 | (6) |
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Pteridine and Nitric Oxide Biosynthesis in Physarum Polycephalum |
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223 | (6) |
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Pteridines and Pigment Granules of Wing Scales Concerned with Sexual Difference in Wing's Capability Reflecting Near-UV Rays in the Japanese Cabbage Butterfly, Pieris Rapae Crucibora |
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229 | (6) |
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Tetrahydrobiopterin, Nitric Oxide Synthesis and cGMP Concentrations in Mutants of Physarum Polycephalum with Altered Sporulation Behavior |
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235 | (6) |
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BH4 and NOS are Involved in Light Controlled Development of Sporangiophores in the Fungus Phycomyces Blakesleeanus |
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241 | (6) |
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Determination of Tetrahydropterins as Native Pteridines in Two V-Microorganisms, Tetrahymena Pyriformis and E. coli |
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247 | (6) |
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Identification of the Sulfurtransfer Pathway for the Generation of the Dithiolene Moiety of Molybdopterin in Escherichia Coli |
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253 | (6) |
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| 5. Tetrahydrobiopterin and Endothelial Function |
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Tetrahydrobiopterin and Vascular Endothelial Function |
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259 | (6) |
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L-Ascorbic Acid Increases Intracellular Tetrahydrobiopterin Via a Chemical Stabilization and Potentiates Nitric Oxide Synthesis in Endothelial Cells |
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265 | (6) |
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The Redox Status of Bound Pterin Cofactor Determines Whether eNOS Produces NO or Superoxide Anion: [3H]-BH4 Binding Studies Provide Insights into Vascular Pathophysiology |
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271 | (6) |
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| 6. Clinical Aspects of Pteridines |
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Sepiapterin Reductase Deficiency: Molecular Analysis in a New Case Presenting with Neurotransmitter Deficiency Without Hyperphenylalaninemia |
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277 | (8) |
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Molecular Basis of DOPA-Responsive Dystonia |
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285 | (6) |
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Human Nigrostriatal Dopamine Neurons Express Low Levels of GTP Cyclohydrolase I mRNA |
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291 | (6) |
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Immunosuppressive Effects of the 4-Amino Analogue of Tetrahydrobiopterin |
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297 | (4) |
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Tetrahydrobiopterin Responsive Hyperphenylalaninemia Without Biopterin Deficiency |
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301 | (4) |
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The Fate of Intravenously Administered Tetrahydrobiopterin and its Implications for Heterologous Gene Therapy of Phenylketonuria |
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305 | (4) |
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Influence of Hydrogen Peroxide (HiO2) on Pterin Homeostasis in the Depigmentation Disorder Vitiligo |
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309 | (10) |
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Catechol-O-Methyltransferase Inhibition in the Treatment of Tetrahydrobiopterin Deficiency |
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319 | (10) |
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Changes in Dihydropteridine Reductase (DHPR) Activity of the Occupationally Lead Exposed Workers |
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329 | (6) |
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Clinical Utility of Pteridine Measurement in Cerebrospinal Fluid |
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335 | (6) |
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Effect of Ascorbic Acid in Measurement of Serum Pteridine Concentration |
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341 | (4) |
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The Effect of Tetrahydrobiopterin (BH4) on Sperm Motility |
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345 | (4) |
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Tetrahydrobiopterin Deficiency in Diabetic Rats |
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349 | (6) |
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The Effect of Tetrahydrobiopterin (BH4) on Diabetic Nephropathy in Streptozotocin (Stz) Induced Diabetic Rats |
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355 | (4) |
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Determination of Sepiapterin and Sepiapterin Reductase in Human Skin |
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359 | (6) |
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| 7. Neopterin |
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Neopterin, an Immunodiagnostie and Oxidative Stress Indicator |
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365 | (6) |
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Role of Neopterin in Immune Monitoring in Transplant Medicine |
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371 | (6) |
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Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines |
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377 | (6) |
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Determination of Neopterin Levels in Gingival Crevicular Fluid (GCF) |
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383 | (4) |
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Neopterin and Biopterin Levels in Pregnancy |
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387 | (6) |
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| 8. Tetrahydrobiopterin and Cell Death |
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Tetrahyrdobiopterin (BH4)-Mediated Neuronal Death Following Intrastriatal Kainic Acid: Implications for Parkinson's Disease |
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393 | (6) |
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Inhibition of Oxidative Stress During Developmental Cell Death: Cellular and Behavioral Effects |
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399 | (6) |
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The Role of Tetrahydrobiopterin (BH4) in Trophic Factor Withdrawal-Induced Apoptosis in PC12 Cells |
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405 | (4) |
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Apoptotic Death of PC12 Cells Induced by Ischemia-Like Conditions is Mediated by Tetrahydrobiopterin (BH4) Metabolism |
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409 | (6) |
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| 9. Folate and Antifolate Chemistry |
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New Approaches Towards Inhibitors of Folate-Dependent Enzymes: Rapid Synthesis of 5-Deazapterins from Uracil Derivatives |
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415 | (6) |
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Solid and Solution Phase Strategies for the Synthesis of Potential Inhibitors of Folate Biosynthesis |
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421 | (6) |
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Progress Towards the Synthesis of Pyrimidodiazepine-Based Folates as Potential Inhibitors of Glycinamide Ribonucleotide Formyltransferase |
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427 | (6) |
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| 10. Antifolates |
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Role of P53 Status on Sensitivity to Thymidylate Synthase Inhibitors and Induction of Apoptosis |
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433 | (6) |
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Synthesis of N-[4-[(2-Amino-6-Methyl-3,4-Dihydro-4-Oxo-7h-Pyrrolo[2,3-D]-Pyrimidin-5-YI)Methyl]Benzoyl]-L-Glutamic Acid as an Antifolate |
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439 | (6) |
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Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3-D]Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo[2,3-D]Pyrimidine on Antifolate Activity |
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445 | (6) |
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Selection of Methotrexate-Resistant Lactobacillus Casei in the Presence of Folate or 5-Formyl-Tetrahydrofolate Affects the Resistance Mechanism |
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451 | (6) |
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Molecular Mechanisms of Resistance to Antimalarial Antifolate Drug Pyrimethamine-Sulfadoxine |
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457 | (4) |
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5-Fluorouracil Induction of Fas and Apoptosis in Colon Cancer Patients: Relation of Clinical Outcome with Thymidylate Synthase, Mcl-1 and Rb |
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461 | (6) |
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Synthesis of 2- or 4-Seleno Analogues of dUMP and FdUMP, and the Corresponding Nucleosides. Interactions with Mammalian Tumor Thymidylate Synthase of the Selenonucleotides and Inhibition of Tumor Cell Growth by the Selenonucleosides |
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467 | (6) |
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Induction of Resistance to the Multi-Targeted antifolate MTA (Ly231514) in Widr Human Colon Cancer Cells |
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473 | (6) |
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| 11. Folate: One Carbon Metabolism Enzymes |
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Mutational Studies of an Essential Glutamate Residue in Escherichia coli Folylpolyglutamate Synthetase with a Role in ATP Binding |
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479 | (6) |
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Rapid Purification of the T-Protein of the Glycine Cleavage System from Rabbit Liver |
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485 | (6) |
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Effects of Cellular Glycine on Cell Proliferation |
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491 | (4) |
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Microarray Analysis of Genes Induced by Methionine Starvation and Growth on Different Sulfur Sources in Yeast |
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495 | (6) |
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| 12. Folate Enzymes: Dihydrofolate Reductase and Thymidylate Synthase |
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Gene Structure and Expression of Trichinella spiralis Thymidylate Synthase |
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501 | (6) |
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Lack of Mutahon of L1210 Thymidylate Synthase with Altered Sensitivity to FdUMP Inhibition |
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507 | (6) |
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Enzymes of Thymidylate Biosynthesis in Trichinella pseudospiralis Muscle Larvae and Caenorhabditis elegans Dauer Larvae |
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513 | (6) |
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Thymidylate Synthase Heterogeneity Assessed by Monoclonal Antibodies |
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519 | (6) |
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Structure-Based Modeling of Reversed N9-C10 Bridge Antifols with Human, Pc and Tg DHFR |
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525 | (6) |
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| 13. Folate: Methionine Cycle Enzymes |
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Regulation of Mammalian Methionine Synthase by B12 |
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531 | (6) |
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Biochemical Studies of Human Methionine Synthase Reductase |
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537 | (6) |
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| 14. Methyltransferases and Methylation Reactions |
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Model Studies for the B12 Dependent Methyltransferases |
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543 | (6) |
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Betaine-Homocysteine S-Methyl-Transferase (BHMT) Transcription is Inhibited by S-Adenosylmethionine (AdoMet) |
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549 | (8) |
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Can Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular Methyltransferases? |
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557 | (6) |
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The Neuropathy of Disturbed Brain Methylation Reactions |
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563 | (6) |
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Dopamine-Stimulated Solid-State Signaling: A Novel Role for Single-Carbon Folates in Human Attention |
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569 | (6) |
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| 15. Folate and Homocysteine and Neural Tube Defects |
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Is Moderate Hyperhomocysteinemia Due to Folic Acid Depletion Rather than Insufficient Dietary Intake? |
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575 | (6) |
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C677t MTHFR Genotype is a Risk Factor for Thromboembolism: Comparison of T Allele Frequency and Homocysteine Level Between Female Thromboembolic and Non-Thromboembolic Vascular Patients, NTD Mothers and Matched NTD Controls |
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581 | (6) |
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Molecular Bases of Hyper-Homocysteinemia Due to Inborn Errors of Folate and Cobalamin Metabolism |
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587 | (6) |
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Vitamin B6 (PLP) and Neural Tube Defects: Is There an Association? |
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593 | (8) |
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| 16. Folate: Analysis and Nutrition |
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Erythrocyte Folate Levels in Operating Room Personnel |
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601 | (8) |
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A Human Ileostomy Model to Determine Folate Bioavailability From Food |
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609 | (6) |
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Channel Coulometric Electrochemical Detection for the Identification of Polyglutamate Homology Amongst Cellular Folates |
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615 | (4) |
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Gastro-Intestinal pH Modulates Facile Interconvertion of Native Formylfolates During Absorption |
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619 | (4) |
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Control Of Folate Production in Lactic Acid Bacteria by Using Metabolic Engineering |
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623 | (8) |
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| 17. Folate Transport |
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Evidence for a Cryptic Gene that Enables E. coli to Specifically Transport Folate Analogs |
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631 | (6) |
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Folate Transport Abnormalities and Congenital Defects |
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637 | (6) |
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Role of Multidrug Resistance Proteins (MRP) in Resistance to Antifolates and Folate Homeostasis |
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643 | (6) |
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Kinetics Of Reduced Folate Carrier- and Membrane-Associated Folate Receptor-Mediated Transport of Antifolates |
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649 | (6) |
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Cell Biology and Regulation of the Intestinal Folate Absorption Process |
|
|
655 | (6) |
|
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| Participants |
|
661 | (12) |
| Index |
|
673 | |