Chiral Separation Techniques A Practical Approach
by Subramanian, Ganapathy-
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Summary
Author Biography
A chemistry graduate from Madras, India, he gained his doctorate from the University of Glasgow for work on natural products, and his main research interests lie in the utilization of natural material separation processes and bio-conversions.
Dr. Subramanian has written and edited a number of books and articles in the field of biotechnology. For the last 10 years, he has been organizing conferences promoting the integration and knowledge exchange between academia and industry.
Table of Contents
| Preface | |
| List of Contributors | |
| Method Development and Optimization of Enantioseparations Using Macrocyclic Glycopeptide Chiral Stationary Phases | |
| Introduction | |
| Structural Characteristics of Macrocyclic Glycopeptide CSPs | |
| Enantioselectivity as a Function of Molecular Recognition | |
| Complementary Effects | |
| Method Development | |
| Optimization Procedures | |
| Amino Acid and Peptide Analysis | |
| Conclusion.Acknowledgments | |
| References | |
| Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis | |
| Introduction | |
| Structures of Polysaccharide Chiral Selectors | |
| Properties of Polysaccharide CSPs | |
| Applications | |
| Optimization of Chiral Separations | |
| Chiral Recognition Mechanisms | |
| Chiral Separation by Sub- and Supercritical Fluid Chromatography | |
| Chiral Separation by Capillary Electrochromatography | |
| Chiral Separation by Thin-layer Chromatography | |
| Chiral Separation by Capillary Electrophoresis | |
| Conclusion | |
| References | |
| Analytical and Preparative Potential of Immobilized Polysaccharide-derived Chiral Stationary Phases | |
| Introduction | |
| Scope of Immobilized Polysaccharide-derived CSPs | |
| Beneficial Characteristics of Immobilized Polysaccharide-derived CSPs | |
| Method Development on Immobilized Polysaccharide-derived CSPs | |
| Regeneration of Immobilized CSPs - Why, How and When | |
| Conclusions and Perspectives | |
| References | |
| Chiral Separations Using Supercritical Fluid Chromatography | |
| Introduction | |
| Overview of SFC | |
| Chiral Stationary Phases in SFC | |
| Mobile Phase Effects in SFC | |
| Preparative-scale Separations | |
| References | |
| Chiral Separation by Ligand Exchange | |
| Introduction | |
| Chiral Ligand-exchange Chromatography | |
| Complexation Gas Chromatography | |
| LE-Electromigration Techniques | |
| List of Abbreviations | |
| References | |
| Advances in Simulated Moving Bed Chromatographic Separations | |
| Introduction | |
| Modeling Strategies | |
| Simulation | |
| Novel SMB Configurations | |
| Improvements in Operation Conditions Evaluation (Separation Volume Method) | |
| Conclusions | |
| References | |
| Less Common Applications of Enantioselective HPLC Using the SMB Technology in the Pharmaceutical Industry | |
| Introduction - From an Emerging Technology to a Classical Unit Operation | |
| Unbalanced Separations and Multi-component Separations Using SMB | |
| Unusual Isotherms and Adsorption Behavior | |
| Applications of Various Column Configurations | |
| Application of Solvent Gradients | |
| Chemistry and Racemization | |
| Future Developments | |
| Conclusion | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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