Chiral Separation Techniques A Practical Approach

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Edition: 3rd
Format: Hardcover
Pub. Date: 2006-12-15
Publisher(s): Wiley-VCH
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Summary

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Author Biography

With over 30 years experience in both industry and academia, Ganapathy Subramanian is a biotechnology consultant working in the application and development of processing, purification methodologies and chromatographic systems for large-scale use in environmental science, food science, perfumery cosmetics and pharmaceuticals. He has also taught extensively in the area of food and medical technology.
A chemistry graduate from Madras, India, he gained his doctorate from the University of Glasgow for work on natural products, and his main research interests lie in the utilization of natural material separation processes and bio-conversions.
Dr. Subramanian has written and edited a number of books and articles in the field of biotechnology. For the last 10 years, he has been organizing conferences promoting the integration and knowledge exchange between academia and industry.

Table of Contents

Preface
List of Contributors
Method Development and Optimization of Enantioseparations Using Macrocyclic Glycopeptide Chiral Stationary Phases
Introduction
Structural Characteristics of Macrocyclic Glycopeptide CSPs
Enantioselectivity as a Function of Molecular Recognition
Complementary Effects
Method Development
Optimization Procedures
Amino Acid and Peptide Analysis
Conclusion.Acknowledgments
References
Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis
Introduction
Structures of Polysaccharide Chiral Selectors
Properties of Polysaccharide CSPs
Applications
Optimization of Chiral Separations
Chiral Recognition Mechanisms
Chiral Separation by Sub- and Supercritical Fluid Chromatography
Chiral Separation by Capillary Electrochromatography
Chiral Separation by Thin-layer Chromatography
Chiral Separation by Capillary Electrophoresis
Conclusion
References
Analytical and Preparative Potential of Immobilized Polysaccharide-derived Chiral Stationary Phases
Introduction
Scope of Immobilized Polysaccharide-derived CSPs
Beneficial Characteristics of Immobilized Polysaccharide-derived CSPs
Method Development on Immobilized Polysaccharide-derived CSPs
Regeneration of Immobilized CSPs - Why, How and When
Conclusions and Perspectives
References
Chiral Separations Using Supercritical Fluid Chromatography
Introduction
Overview of SFC
Chiral Stationary Phases in SFC
Mobile Phase Effects in SFC
Preparative-scale Separations
References
Chiral Separation by Ligand Exchange
Introduction
Chiral Ligand-exchange Chromatography
Complexation Gas Chromatography
LE-Electromigration Techniques
List of Abbreviations
References
Advances in Simulated Moving Bed Chromatographic Separations
Introduction
Modeling Strategies
Simulation
Novel SMB Configurations
Improvements in Operation Conditions Evaluation (Separation Volume Method)
Conclusions
References
Less Common Applications of Enantioselective HPLC Using the SMB Technology in the Pharmaceutical Industry
Introduction - From an Emerging Technology to a Classical Unit Operation
Unbalanced Separations and Multi-component Separations Using SMB
Unusual Isotherms and Adsorption Behavior
Applications of Various Column Configurations
Application of Solvent Gradients
Chemistry and Racemization
Future Developments
Conclusion
Table of Contents provided by Publisher. All Rights Reserved.

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