Discovering Complexity Decomposition and Localization as Strategies in Scientific Research

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Edition: Revised
Format: Paperback
Pub. Date: 2010-08-06
Publisher(s): The MIT Press
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Summary

In Discovering Complexity,William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in divergent explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility-the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized. When Discovering Complexitywas originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993.

Author Biography

William Bechtel is Professor of Philosophy at the University of California, San Diego. He is the author of Mental Mechanisms: Philosophical Perspectives on Cognitive Neuroscience and other books. Robert C. Richardson is Charles Phelps Taft Professor of Philosophy and University Distinguished Research Professor at the University of Cincinnati. He is the author of Evolutionary Psychology as Maladapted Psychology (MIT Press, 2007). Both are Fellows of the American Association for the Advancement of Science.

Table of Contents

Preface to the MIT Press Editionp. xi
Preface to the Original Editionp. xiii
Introduction: Discovering Complexity-Further Perspectivesp. xvii
The Appearance of a New Mechanistic Philosophy of Sciencep. xvi
Discovery Heuristics: Conceptual and Experimentalp. xx
Decomposition and Localizationp. xxviii
Recomposing and Situating Mechanismsp. xxxvii
Model Systems, Conserved Mechanisms, and Generalizationp. xl
Rethinking Emergencep. xliv
Conclusionp. xlvii
Scientific Discovery and Rationality
Cognitive Strategies and Scientific Discoveryp. 3
Rationalizing Scientific Discoveryp. 3
Procedural Rationalityp. 11
Complex Systems and Mechanistic Explanationsp. 17
Mechanistic Explanationp. 17
Decomposition and Localizationp. 23
Hierarchy and Organizationp. 27
Conclusion: Failure of Localizationp. 31
Emerging Mechanisms
Introductionp. 35
Identifying the Locus of Controlp. 39
Introduction: Identifying System and Contextp. 39
External Control: The Environment as a Controlp. 41
Internal Control: The System as a Controlp. 47
Fixing on a Locus of Control: the Cell in Respirationp. 51
Conclusion: Localization of Functionp. 59
Direct Localizationp. 63
Introduction: Relocating Controlp. 63
Phrenology and Cerebral Localizationp. 65
Competing Models of Cellular Respirationp. 72
Conclusion: Direct Localization and Competing Mechanismsp. 88
The Rejection of Mechanismp. 93
Introduction: Mechanism and Its Opponentsp. 93
Flourens and the Integrity of the Nervous Systemp. 95
The Vitalist Opposition to Mechanistic Physiologyp. 99
Conclusion: Setting for Descriptionsp. 113
Elaborating Mechanisms
Introductionp. 119
Complex Localizationp. 125
Introduction: Constraints on Localizationp. 125
Top-Down Constraintsp. 128
Bottom-Up Constraintsp. 138
Conclusion: The Rise and Decline of Decomposabilityp. 145
Integrated Mechanismsp. 149
Introduction: Replacing a Direct Localizationp. 149
Direct Localization of Fermentation in Zymasep. 153
A Complex Linear Model of Fermentationp. 156
An Integrated System Responsible for Fermentationp. 163
Conclusion: The Discovery of Integrationp. 168
Reconstituting the Phenomenap. 173
Introduction: Biochemical Geneticsp. 173
Classical Geneticsp. 175
Developmental Geneticsp. 181
One Gene/One Enzymep. 188
Conclusion: Reconstituting the Phenomenap. 192
Emergent Mechanism
Introductionp. 199
"Emergent" Phenomena in Interconnected Networksp. 202
Introduction: Dispensing with Modulesp. 202
Hierarchical Control: Hughlings Jackson's Analysis of the Nervous Systemsp. 203
Parallel Distributed Processing and Cognitionp. 210
Distributed Mechanisms for Genomic Regulationp. 223
Conclusion: Mechanistic Explanations without Functional Decomposition and Localizationp. 227
Constructing Causal Explanationsp. 230
Decomposition and Localization in Perspectivep. 230
Four Constraints on Developmentp. 234
Conclusion: Looking Forwardp. 243
Notesp. 245
Referencesp. 257
Indexp. 281
Table of Contents provided by Ingram. All Rights Reserved.

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