Dynamic Combinatorial Chemistry In Drug Discovery, Bioorganic Chemistry, and Materials Science
by Miller, Benjamin L.Edition: 1st
Format: Hardcover
Pub. Date: 2009-12-02
Publisher(s): Wiley
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Summary
This book presents an overview of dynamic combinatorial chemistry (DCC) and fragment-based library methods and how chemists apply them to the problems of lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover basic theory, approaches to binding in proteins and small molecules, molecular recognition, catalyst discovery, click chemistry, "SAR by NMR," and analytical chemistry challenges. A single-source reference about modern methods in fragment-based drug discovery and DCC methods and applications, this is a core resource for chemists building structure libraries and designing compounds.
Author Biography
Benjamin L. Miller is an Associate Professor of Dermatology, Biomedical Engineering, and Biochemistry and Biophysics at the University of Rochester. In addition to his academic credentials, Dr. Miller has industry consulting experience as the founder of Adarza BioSystems and Lighthouse Biosciences.
Table of Contents
| Preface | p. vii |
| Contibutors | p. ix |
| Dynamic Combinatorial Chemistry: An Introduction | p. 1 |
| Protein-Directed Dynamic Combinatorial Chemistry | p. 43 |
| Nucleic Acid-Targeted Dynamic Combinatorial Chemistry | p. 83 |
| Complex Self-Sorting Systems | p. 118 |
| Chiral Selection in DCC | p. 155 |
| Dynamic Combinatorial Resolution | p. 169 |
| Dynamic Combinatorial Chemistry and Mass Spectrometry: A Combined Strategy for High Performance Lead Discovery | p. 201 |
| Dynamic Combinatorial Methods in Materials Science | p. 229 |
| Index | p. 261 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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