Epigenetics in Biology And Medicine

by ;
Edition: 1st
Format: Hardcover
Pub. Date: 2008-09-17
Publisher(s): CRC Press
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Summary

Epigenetic changes are essential to normal development, but these changes can also cause problems including the disabling of genes that suppress tumors. At present, more than a dozen drugs that target epigenetic changes are in clinical trials. Epigenetics in Biology and Medicineoffers a comprehensive overview of epigenetics, both in normal functions and disease states. This book presents contributions from international experts, addressing both theoretical and methodological issues. It discusses cell biology and the role of epigenetics in human, animal, and plant diseases. The text also covers DNA methylation inhibitors, histone modifications, and epigenomics, as well as the impact that diet has on epigenetic changes.

Table of Contents

Editorp. v
Contributorsp. vii
An Introduction to Epigeneticsp. 1
Epigenetics and Cancer: DNA Methylationp. 3
Epigenetics and Cancer: Histone Modificationsp. 17
Epigenetic Drugs: DNA Demethylating Agentsp. 27
Epigenetic Drugs: Histone Deacetylase Inhibitorsp. 49
Sirtuins in Biology and Diseasep. 73
microRNAs in Cell Biology and Diseasesp. 105
Chromatin Modifications by Polycomb Complexesp. 131
Epigenetics and its Genetic Syndromesp. 155
Epigenetics and Immunityp. 175
Etiology of Major Psychosis: Why Do We Need Epigenetics?p. 189
Epigenetics and Cardiovascular Diseasep. 207
Plant Epigeneticsp. 225
Epigenetics, Environment, and Evolutionp. 241
Epigenetics and Epigenomicsp. 261
Indexp. 285
Table of Contents provided by Ingram. All Rights Reserved.

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