• fills the gap between guidelines and primary studies as well as between primary and secondary scientific medical literature
• summarizes the most recent and important findings on treatments for neurological patients
• measures the benefit and, when applicable, the risk of harm inherent in specific neurological interventions
• now includes new non-clinical topics of interest to neurologists such as education and research

Bart M. Demaerschalk, MD, MSc, FRCP(C), Professor of Neurology, Department of Neurology, Mayo Clinic, College of Medicine, Phoenix, AZ, USA

Dean M. Wingerchuk, MD, MSc, FRCP(C), Professor of Neurology, Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ, USA

Contributors vii

Part 1 Evidence-based neurology: introduction

1 Evidence-based neurology in health education 3
Lawrence Korngut, Miguel Bussière and Bart M. Demaerschalk

2 Evidence-based medicine in health research 9
Dean M. Wingerchuk

3 Evidence and ethics 13
Joseph L. Verheijde

Part 2 Evidence-based neurology in the hospital

4 Thunderclap headache 23
Jonathan H. Smith and Todd J. Schwedt

5 Coma 33
Bappaditya Ray and Salah G. Keyrouz

6 Acute ischemic stroke and transient ischemic attack 53
Maria I. Aguilar

7 Spinal cord compression 67
Naresh P. Patel, Christopher A. Payne and Bhavesh M. Patel

8 Delirium 75
William D. Freeman

9 Status epilepticus 81
Kameshwar Prasad, Manya Prasad, Sridharan Ramaratnam and Anthony G. Marson

10 Raised intracranial pressure 87
William David Freeman

11 Traumatic brain injury 93
Miguel Arango, Walter Videtta and Corina Puppo

12 Myasthenia gravis 107
Brent P. Goodman

13 Acute visual loss 113
Byron Roderick Spencer

14 Secondary prevention of stroke 119
Gord Gubitz

Part 3 Evidence-based neurology in the clinic

15 Central nervous system infections 131
Gloria von Geldern and Avindra Nath

16 Evidence-based neuro-oncology 143
Michael G. Hart and Robin Grant

17 Epilepsy 153
Sridharan Ramaratnam and Anthony G. Marson

18 Cognitive disorders: mild cognitive impairment and Alzheimer’s disease 173
Charlene H. Snyder, Bryan K. Woodruff and Richard J. Caselli

19 Evidence-based treatment of Parkinson’s disease 191
Nicholas D. Child and Bryan T. Klassen

20 Therapies for multiple sclerosis 209
Greg Thaera and Dean M. Wingerchuk

21 Amyotrophic lateral sclerosis 219
Cumara B. O’Carroll, Amelia K. Adcock and Bart M. Demaerschalk

22 Peripheral nerve disorders 235
Jennifer A. Tracy and P. James B. Dyck

23 Critical illness neuromyopathy 243
Brent P. Goodman and Andrea J. Boon

24 Muscle disorders 249
Amelia K. Adcock, Cumara B. O’Carroll and Bart M. Demaerschalk

25 Sleep disorders 257
Joyce K. Lee-Iannotti

26 Acute migraine attacks 267
E. Anne MacGregor, Rashmi B. Halker and Bert B. Vargas

27 Therapy of vestibular disorders nystagmus and cerebellar ataxia 279
Michael Strupp and Thomas Brandt

28 Neuro-ophthalmology 291
Martin Sutton-Brown and Jason J. S. Barton

29 Therapeutic connection in neurorehabilitation: theory evidence and practice 303
Nicola M. Kayes, Kathryn M. McPherson and Paula Kersten

Part 4 Telemedicine feature

30 Evidence-based teleneurology practice 321
William D. Freeman, Kevin M. Barrett, Kenneth A Vatz and Bart M. Demaerschalk

Index 325