Flow and Microreactor Technology in Medicinal Chemistry,9783527346899

Flow and Microreactor Technology in Medicinal Chemistry

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Edition: 1st
ISBN13: 9783527346899
ISBN10: 3527346899
Format: Hardcover
Pub. Date: 2022-06-20
Publisher(s): Wiley-VCH
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Summary

Computer-controlled chemical synthesis using flow chemistry microreactors is the key enabling technology for the chemistry laboratory of the future. Early adopters of this ground-breaking technology describe current and future uses in medicinal chemistry.

Author Biography

Esther Alza is the Manager of ERTFLOW at the Institute of Chemical Research of Catalonia (ICIQ), in Tarragona, Spain. Having obtained her PhD from ICIQ working on asymmetric catalysis and flow chemistry, she moved to the University of Cambridge as a Wellcome Trust Postdoctoral Fellow to work on medicinal chemistry. After this, she returned to ICIQ to lead the establishment of ERTFLOW as technology development unit and future spin-off company. ERTFOW is Oriented to provide research and development services in the fields of catalysis and flow processes.

Table of Contents

INTRODUCTION
Continuous flow technology for the fine chemical and pharmaceutical Industries.
CASE STUDIES
Novel (forbidden) chemistry towards NCE to increase chemical space
Enantioselective catalysis in continuous flow to improve throughput
Synthesis in continuous flow of important drugs and APIs
TECHNOLOGIES
HTE in continuous flow to speed library synthesis
Integration systems with continuous synthesis and biological screening
Microreactors for target validation (organ on a chip)
Process Analytical Technologies (PAT) and tools for controlled process design
Artificial Intelligence, Machine Learning and automatization in drug discovery
Emerging market challenges and on demand manufacturing

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