Handbook of Statistical Genetics, 3rd Edition

The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research.

List of contributors Editor's Preface to the Third Edition Glossary of Terms Abbreviations and Acronyms Chromosome Maps Statistical Significance in Biological Sequence Bayesian Methods in Biological Sequence Analysis Statistical Approaches in Eukaryotic Gene Prediction Comparative Genomics Analysis of Microarray Gene Expression Data Inferences from microarray data Bayesian methods for microarray data eQTL analyses Protein Structure Metabonomics Adaptive Molecular Evolution Genome Evolution Probabilistic Models for the Study of Protein Evolution Application of the Likelihood Function in Phylogenetic Phylogenetics: Parsimony, Networks and Distances Evolutionary Quantitative Genetics Quantitative Trait Loci in Inbred Lines Mapping Quantitative Trait Loci Outbred Pedigrees Inferences from Mixed Models in Quantitative Genetics Marker-Assisted Selection and Introgression Mathematical Models in Population Genetics Inference, simulation and enumeration of pedigrees and genealogies Graphical modelling in genetics Coalescent Theory Inference Under the Coalescent Linkage Disequilibrium, recombination and selection Inferences from Spatial Population Genetics Analysis of Population Subdivision Conservation Genetics Human population genetics/history Epidemiology and Genetic Epidemiology Linkage Analysis Nonparametric Linkage Admixture mapping and population structure in association studies Population Association Genome-wide association studies Family-based association studies Cancer genetics Epigenetics Ethics Insurance Forensics Reference Author Index Subject Index