Heat Shock Proteins in Myocardial Protection
by Kukreja,Rakesh C.Format: Hardcover
Pub. Date: 2000-08-01
Publisher(s): CRC Press
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Summary
Table of Contents
| Stress Proteins in Myocardial Protection | p. 1 |
| Heat Stress and the Stress Response | p. 1 |
| Are Stress Proteins Protective? | p. 2 |
| Evidence for the Ability of Stress Proteins to Protect the Cell | p. 2 |
| Conclusions | p. 9 |
| Heat Stress Proteins: A Possible Route to Myocardial Protection | p. 15 |
| Introduction | p. 15 |
| What Are Heat Stress Proteins? | p. 16 |
| Introducing the Major Cardiac Heat Stress Proteins | p. 16 |
| Dynamics of Heat Stress Protein Gene Expression and Regulation | p. 18 |
| Relevance to Myocardial Protection | p. 19 |
| Experimental Models | p. 19 |
| Heat Stress and Models Mimicking Cardiac Surgery | p. 20 |
| Transgenic Animal Models: The Answer to Heat Shock Associated Damage? | p. 21 |
| Proposed Mechanisms for HSP-Mediated Protection | p. 22 |
| Conclusion: Is There a Role for Heat Stress in the Armamentarium of Myocardial Protection? | p. 24 |
| Cardioprotection by Stress Proteins | p. 30 |
| The Mammalian Stress Proteins | p. 30 |
| Myocardial Ischemia | p. 32 |
| Cardioprotection by the Stress Proteins | p. 34 |
| Conclusion | p. 36 |
| Role of Heat Shock Proteins, Protein Kinase C and ATP-Sensitive Potassium Channel in Delayed Myocardial Protection | p. 41 |
| Stress and Ischemic Protection | p. 41 |
| Whole-Body Hyperthermia and Delayed Ischemic Protection | p. 42 |
| Delayed Ischemic Preconditioning--Role of Hsp 72 | p. 42 |
| Hsp 72 and Ischemic Protection--Controversies | p. 45 |
| Role of Protein Kinase C | p. 45 |
| Role of KATP Channel | p. 48 |
| Conclusions | p. 50 |
| Hsp 70 and Ischemia Tolerance in the Compromised Heart | p. 55 |
| Stress Proteins in the Aged and Diseased Animal Heart | p. 56 |
| Stress Proteins and Cardiovascular Disease in Humans | p. 58 |
| New Research and Anticipated Developments | p. 61 |
| Conclusions | p. 62 |
| Hsp72 in the Regulation of TNF-[alpha] Production: Mechanistic Implication of Protection Against Postischemic Myocardial Dysfunction | p. 66 |
| Abstract | p. 66 |
| Introduction | p. 66 |
| Hsp70 in Myocardial Protection | p. 67 |
| Myocardial Ischemia and TNF-a Production | p. 68 |
| Hsp70 in the Regulation of TNF-a Production | p. 69 |
| Perspectives | p. 72 |
| Preconditioning of Cardiac Myocytes Studies Using Cultured Neonatal Rat Heart Myocytes and Simulated Ischemia | p. 77 |
| A Model System for Simulated Ischemia/Reperfusion | p. 77 |
| Using the Model to Study Sarcolemmal Processes During Ischemia/Reperfusion | p. 80 |
| Using the Model of Simulated Ischemia in Preconditioning Studies | p. 80 |
| Hsp70 Expression During Preconditioning of Cultured Neonatal Rat Heart Cells | p. 81 |
| The Role of Hsp70 in Preconditioning Cultured Neonatal Rat Heart Cells | p. 83 |
| Antisense, Heat Shock Proteins and the Heart | p. 87 |
| Overview of Antisense Technology | p. 87 |
| Complications and Controls | p. 88 |
| Antisense and the Cardiovascular System | p. 88 |
| Heat Shock Proteins and Antisense | p. 89 |
| Hsp72 (Inducible Hsp70) | p. 89 |
| Heat Shock Protein 60 | p. 90 |
| Small Heat Shock Proteins | p. 92 |
| Other Hsp's | p. 92 |
| Conclusions | p. 93 |
| Stress Proteins in Myocardial Protection: Culture Shock Protein, Heme Oxygenase-1 (Hsp32), Induced by Sublethal Stresses Protects the Heart Against Oxidative Stress | p. 96 |
| Increased HO-1 Expression in Myocardial Cells | p. 97 |
| HO-1-Induced Cardioprotection Against Hypoxia-Reoxygenation Injury | p. 102 |
| Sublethal Stress-Induced HO-1 Expression in Myocardial Cells | p. 103 |
| HO-1 as a Rescue Protein in Pharmacological Preconditioning | p. 105 |
| Conclusions | p. 106 |
| Physiological Role of Heat Shock Protein 27 | p. 109 |
| Hsp27: A Member of Small Hsp Family | p. 109 |
| Heat Shock Response: Thermoresistance and Increased Tolerance to Stress | p. 110 |
| Physiological Functions of Hsp27 | p. 111 |
| Cross-Talk with Oxidative Stress-Inducible Proteins | p. 114 |
| Clinical Significance | p. 115 |
| Summary and Conclusion | p. 116 |
| Ischemia/Reperfusion Injury and Heat Shock Proteins | p. 121 |
| Regulation of Heat Shock Gene Transcription | p. 121 |
| Damage by Ischemia/Reperfusion Injury | p. 122 |
| Induction of Hsp's by Ischemia/Reperfusion in the Heart | p. 124 |
| Hsf Activation by Ischemia/Reperfusion | p. 124 |
| Myocardial Protection Against Ischemia/Reperfusion by Hsp's | p. 125 |
| Signals for Heat Shock Response During Ischemia/Reperfusion | p. 128 |
| Clinical Application and Future Perspective | p. 130 |
| Index | p. 135 |
| Table of Contents provided by Syndetics. All Rights Reserved. |
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