The updated bestselling guide to human metabolism and metabolic regulation

The revised and comprehensively updated new edition of Human Metabolism (formerly Metabolic Regulation – A Human Perspective) offers a current and integrated review of metabolism and metabolic regulation. The authors explain difficult concepts in clear and concise terms in order to provide an accessible and essential guide to the topic. This comprehensive text covers a wide range of topics such as energy balance, body weight regulation, exercise, and how the body copes with extreme situations, and illustrates how metabolic regulation allows the human body to adapt to many different conditions.

This fourth edition has been revised with a new full colour text design and helpful illustrations that illuminate the regulatory mechanisms by which all cells control the metabolic processes necessary for life. The text includes chapter summaries and additional explanatory text that help to clarify the information presented. In addition, the newly revised edition includes more content on metabolic pathways and metabolic diseases. This important resource:

• Is a valuable tool for scientists, practitioners and students across a broad range of health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing
• Includes a full colour text filled with illustrations and additional diagrams to aid understanding
• Offers a companion website with additional learning and teaching resources.

Written for students of medicine, biochemistry, nutrition, dietetics, sports science and nursing, Human Metabolism has been revised and updated to provide a comprehensive review of metabolism and metabolic regulation.

Keith N. Frayn, Emeritus Professor of Human Metabolism, University of Oxford, UK.

Rhys D. Evans, Reader in Metabolic Biochemistry, Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

Preface vi

Abbreviations vii

About the companion website xi

1 The underlying principles of human metabolism 1

2 Cellular aspects of metabolic regulation 48

3 Coordination of metabolism in the whole body 76

4 Digestion and intestinal absorption 93

5 Metabolic specialisation of organs and tissues 118

6 Communication systems 173

7 Integration of carbohydrate, fat and protein metabolism in normal daily life 204

8 Metabolic challenges: Coping with some extreme physiological situations 245

9 Metabolic challenges: Coping with some pathological situations 277

10 Lipoprotein metabolism and atherosclerosis 302

11 Energy balance and body weight regulation 325

12 Diabetes mellitus 346

Index 365