Integrated Strategies For Drug Discovery Using Mass Spectrometry,9780471461272

Integrated Strategies For Drug Discovery Using Mass Spectrometry

by
Edition: 1st
ISBN13: 9780471461272
ISBN10: 047146127X
Format: Hardcover
Pub. Date: 2005-06-29
Publisher(s): Wiley-Interscience
  • Free Shipping Icon

    This Item Qualifies for Free Shipping!*

    *Excludes marketplace orders.

List Price: $242.98

Buy New

Arriving Soon. Will ship when available.
$231.41
Add to Cart

Rent Textbook

Select for Price
Add to Cart
There was a problem. Please try again later.

Used Textbook

We're Sorry
Sold Out

eTextbook

We're Sorry
Not Available

Buy from our Marketplace starting at $133.79

How Marketplace Works:

  • This item is offered by an independent seller and not shipped from our warehouse
  • Item details like edition and cover design may differ from our description; see seller's comments before ordering.
  • Sellers much confirm and ship within two business days; otherwise, the order will be cancelled and refunded.
  • Marketplace purchases cannot be returned to eCampus.com. Contact the seller directly for inquiries; if no response within two days, contact customer service.
  • Additional shipping costs apply to Marketplace purchases. Review shipping costs at checkout.

Summary

* Shares historical background information on various techniques to aid in the understanding of how and why new methods are now being employed to analyze samples

Author Biography

MIKE S. LEE, PHD is President of Milestone Development Services. He is actively involved with consulting, workshops, and symposia to connect industry needs with innovative technologies and solutions. His research interests include the applications of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recent work has involved the development of automated orthogonal control systems for electrospray ionization. Formerly, Dr. Lee was director of analytical research and development at Bristol-Myers Squibb (BMS) Pharmaceutical Research Institute where he led interdisciplinary teams that contributed to the Food and Drug Administration's approval of Buspar® and Serzone, and the accelerated development and approval of TAXOL. Dr. Lee is a member of the American Society of Mass Spectrometry, American Association of Pharmaceutical Scientists, and the American Chemical Society. In addition, he has authored over forty scientific papers and issued patents.

Table of Contents

Preface ix
List of Contributors
xiii
Acknowledgements xvii
Miniaturized Formats for Efficient Liquid Chromatography Mass Spectrometry-Based Proteomics and Therapeutic Development
01(26)
Gary A. Valaskovic
Neil L. Kelleher
Mass-Spectrometry-Based Drug Screening Assays for Early Phases in Drug Discovery
27(44)
Marshall M. Siegel
ESI-FTICR as a High Throughput Drug Discovery Platform
71(24)
Kristin A. Sannes-Lowery
Lendell L. Cummins
Shuo Chen
Jared J. Drader
Steven A. Hofstadler
Mass Spectrometry--Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery
95(26)
Thomas P. Conrads
Haleem J. Issaq
Josip S. Blonder
Timothy D. Veenstra
Metabonomic Applications in Toxicity Screening and Disease Diagnosis
121(28)
John P. Shockcor
Elaine Holmes
The Central Role of Mass Spectrometry in Natural Products Discovery
149(40)
Jeffrey R. Gilbert
Paul Lewer
Dennis O. Duebelbeis
Andrew W. Carr
Application of Mass Spectrometry to Compound Library Generation, Analysis, and Management
189(42)
Xueheng Cheng
Jill Hochlowski
A Combinatorial Process for Drug Discovery
231(30)
David S. Wagner
Richard W. Wagner
Frank Schoenen
H. Mario Geysen
Application of Technological Advances in Biotransformation Studies
261(28)
Carmen L. Fernandez-Metzler
Raju Subramanian
Richard C. King
Applications of Mass Spectrometry for the Characterization of Reactive Metabolites of Drugs in Discovery
289(26)
Jim Wang
Jack Wang
Margaret Davis
William DeMaio
JoAnn Scatina
Rasmy Talaat
Advances in High Throughput Quantitative Drug Discovery Bioanalysis
315(44)
Bradley L. Ackermann
Michael J. Berna
Anthony T. Murphy
New Strategies for the Implementation and Support of Bioanalysis in a Drug Metabolism Environment
359(20)
Walter A. Korfmacher
An Integrated LC-MS Strategy for Preclinical Candidate Optimization
379(24)
Jonathan L. Josephs
Mark Sanders
New Approaches for Method Development and Purification in Lead Optimization
403(30)
Yining Zhao
David J. Semin
High Throughput Metabolic and Physicochemical Property Analysis: Strategies and Tactics for Impact on Drug Discovery Success
433(26)
Edward H. Kerns
Li Di
Organ Perfusion and Mass Spectrometry
459(18)
C. Gerald Curtis
Ben Chien
David Bar-Or
Kumar Ramu
Sample Preparation for Drug Discovery Bioanalysis
477(34)
David A. Wells
Automation
511(32)
John D. Laycock
Thomas Hartmann
Index 543

An electronic version of this book is available through VitalSource.

This book is viewable on PC, Mac, iPhone, iPad, iPod Touch, and most smartphones.

By purchasing, you will be able to view this book online, as well as download it, for the chosen number of days.

Digital License

You are licensing a digital product for a set duration. Durations are set forth in the product description, with "Lifetime" typically meaning five (5) years of online access and permanent download to a supported device. All licenses are non-transferable.

More details can be found here.

A downloadable version of this book is available through the eCampus Reader or compatible Adobe readers.

Applications are available on iOS, Android, PC, Mac, and Windows Mobile platforms.

Please view the compatibility matrix prior to purchase.