
An Introduction to Forensic Genetics
by William Goodwin (University of Central Lancashire, UK); Adrian Linacre (Centre for Forensic Science, University of Strathclyde, Glasgow, UK); Sibte Hadi (University of Central Lancashire, UK)-
This Item Qualifies for Free Shipping!*
*Excludes marketplace orders.
Buy New
Rent Textbook
Rent Digital
Used Textbook
We're Sorry
Sold Out
How Marketplace Works:
- This item is offered by an independent seller and not shipped from our warehouse
- Item details like edition and cover design may differ from our description; see seller's comments before ordering.
- Sellers much confirm and ship within two business days; otherwise, the order will be cancelled and refunded.
- Marketplace purchases cannot be returned to eCampus.com. Contact the seller directly for inquiries; if no response within two days, contact customer service.
- Additional shipping costs apply to Marketplace purchases. Review shipping costs at checkout.
Summary
Table of Contents
Preface | p. ix |
About the Authors | p. x |
Introduction to forensic genetics | p. 1 |
Forensic genetics | p. 1 |
A brief history of forensic genetics | p. 2 |
References | p. 5 |
DNA structure and the genome | p. 7 |
DNA structure | p. 7 |
Organization of DNA into chromosomes | p. 7 |
The structure of the human genome | p. 9 |
Genetic diversity of modern humans | p. 11 |
The genome and forensic genetics | p. 11 |
Tandem repeats | p. 12 |
Single nucleotide polymorphisms (SNPs) | p. 13 |
Further reading | p. 14 |
References | p. 14 |
Biological material - collection, characterization and storage | p. 17 |
Sources of biological evidence | p. 17 |
Collection and handling of material at the crime scene | p. 19 |
Identification and characterization of biological evidence | p. 19 |
Evidence collection | p. 20 |
Sexual and physical assault | p. 21 |
Presumptive testing | p. 21 |
Storage of biological material | p. 23 |
References | p. 24 |
DNA extraction and quantification | p. 27 |
DNA extraction | p. 27 |
General principles of DNA extraction | p. 27 |
DNA extraction from challenging samples | p. 30 |
Quantification of DNA | p. 32 |
DNA IQ system | p. 36 |
References | p. 36 |
The polymerase chain reaction | p. 39 |
The evolution of PCR-based profiling in forensic genetics | p. 39 |
DNA replication - the basis of the PCR | p. 40 |
The components of PCR | p. 40 |
The PCR process | p. 42 |
PCR inhibition | p. 44 |
Sensitivity and contamination | p. 45 |
The PCR laboratory | p. 46 |
Further reading | p. 48 |
References | p. 48 |
The analysis of short tandem repeats | p. 51 |
Structure of STR loci | p. 51 |
The development of STR multiplexes | p. 51 |
Detection of STR polymorphisms | p. 54 |
Interpretation of STR profiles | p. 56 |
Further reading | p. 61 |
References | p. 61 |
Assessment of STR profiles | p. 65 |
Stutter peaks | p. 65 |
Split peaks (+/-A) | p. 65 |
Pull-up | p. 67 |
Template DNA | p. 68 |
Overloaded profiles | p. 68 |
Low copy number DNA | p. 68 |
Peak balance | p. 70 |
Mixtures | p. 70 |
Degraded DNA | p. 71 |
References | p. 73 |
Statistical interpretation of STR profiles | p. 75 |
Population genetics | p. 75 |
Deviation from the Hardy-Weinberg equilibrium | p. 76 |
Statistical tests to determine deviation from the Hardy-Weinberg equilibrium | p. 77 |
Estimating the frequencies of STR profiles | p. 78 |
Corrections to allele frequency databases | p. 78 |
Which population frequency database should be used? | p. 83 |
Conclusions | p. 83 |
Further reading | p. 84 |
References | p. 84 |
The evaluation and presentation of DNA evidence | p. 87 |
Hierarchies of propositions | p. 87 |
Likelihood ratios | p. 89 |
Two fallacies | p. 93 |
Comparison of three approaches | p. 94 |
Further reading | p. 95 |
References | p. 95 |
Databases of DNA profiles | p. 97 |
The UK National DNA database (NDNAD) | p. 97 |
International situation | p. 102 |
References | p. 104 |
Kinship testing | p. 105 |
Paternity testing | p. 105 |
Identification of human remains | p. 111 |
Further reading | p. 112 |
References | p. 112 |
Single nucleotide polymorphisms | p. 115 |
SNPs - occurrence and structure | p. 115 |
Detection of SNPs | p. 115 |
SNP detection for forensic applications | p. 117 |
Forensic applications of SNPs | p. 119 |
SNPs compared to STR loci | p. 120 |
Further reading | p. 121 |
References | p. 121 |
Lineage markers | p. 125 |
Mitochondria | p. 125 |
Applications of mtDNA profiling | p. 127 |
The Y chromosome | p. 130 |
Forensic applications of Y chromosome polymorphisms | p. 131 |
Further reading | p. 132 |
References | p. 133 |
Forensic parameters | p. 137 |
Useful web links | p. 139 |
Glossary | p. 141 |
Abbreviations | p. 145 |
Index | p. 147 |
Table of Contents provided by Ingram. All Rights Reserved. |
An electronic version of this book is available through VitalSource.
This book is viewable on PC, Mac, iPhone, iPad, iPod Touch, and most smartphones.
By purchasing, you will be able to view this book online, as well as download it, for the chosen number of days.
Digital License
You are licensing a digital product for a set duration. Durations are set forth in the product description, with "Lifetime" typically meaning five (5) years of online access and permanent download to a supported device. All licenses are non-transferable.
More details can be found here.
A downloadable version of this book is available through the eCampus Reader or compatible Adobe readers.
Applications are available on iOS, Android, PC, Mac, and Windows Mobile platforms.
Please view the compatibility matrix prior to purchase.