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Genetic counseling and the laws of probability |
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1 | (15) |
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Genetic counseling and the concept of risk |
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1 | (2) |
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3 | (3) |
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The binomial distribution |
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6 | (4) |
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10 | (5) |
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Autosomal dominant inheritance |
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15 | (21) |
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15 | (8) |
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23 | (1) |
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Disorders with late onset |
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24 | (3) |
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Parents have two different autosomal dominant disorders |
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27 | (2) |
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Parents have the same autosomal dominant disorder |
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29 | (2) |
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Affected siblings born to healthy parents |
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31 | (3) |
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34 | (2) |
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Autosomal recessive inheritance |
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36 | (24) |
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Hardy---Weinberg equilibrium |
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36 | (2) |
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Risk to the offspring of a healthy sibling |
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38 | (2) |
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Risks to the extended family |
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40 | (2) |
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Risks to the offspring of an affected homozygote |
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42 | (3) |
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Two brothers marry two sisters |
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45 | (1) |
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Siblings with different autosomal recessive disorders |
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46 | (1) |
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Allowing for separate mutations |
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47 | (4) |
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51 | (5) |
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Direct mutation analysis and multiple alleles |
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56 | (4) |
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Sex-linked recessive inheritance |
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60 | (22) |
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The prior probability that any female is a carrier of a sex-linked recessive disorder |
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61 | (1) |
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The probability that the mother of an isolated case is a carrier |
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62 | (1) |
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The carrier risks for female relatives of an isolated case |
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63 | (8) |
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Different mutation rates in males and females |
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71 | (4) |
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Biological fitness is greater than zero |
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75 | (4) |
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Germinal (gonadal) mosaicism |
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79 | (3) |
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The use of linked DNA markers |
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82 | (27) |
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Basic principles of genetic linkage |
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82 | (2) |
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Autosomal dominant inheritance |
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84 | (3) |
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Autosomal recessive inheritance |
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87 | (5) |
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Sex-linked recessive inheritance |
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92 | (3) |
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Using information from flanking markers |
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95 | (3) |
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Disorders with late onset |
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98 | (3) |
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Parental genotypes not known |
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101 | (3) |
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104 | (2) |
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106 | (3) |
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Polygenic and multifactorial inheritance |
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109 | (13) |
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Polygenic inheritance and the Normal distribution |
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110 | (2) |
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The liability/threshold model |
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112 | (1) |
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General principles in counseling for multifactorial disorders |
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113 | (2) |
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Computer program for risk estimation |
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115 | (2) |
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The use of susceptibility loci |
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117 | (3) |
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A philosophical postscript |
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120 | (2) |
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122 | (11) |
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General principles in cancer risk assessment |
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122 | (3) |
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Risk assessment using empiric epidemiological data |
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125 | (2) |
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Risk assessment assuming Mendelian inheritance |
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127 | (4) |
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131 | (2) |
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Balanced chromosome rearrangements |
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133 | (28) |
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Reciprocal translocations |
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135 | (10) |
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Robertsonian translocations |
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145 | (4) |
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149 | (2) |
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151 | (4) |
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155 | (2) |
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157 | (1) |
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Rearrangements involving an X chromosome |
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158 | (3) |
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Other mechanisms of inheritance |
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161 | (23) |
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Sex-linked dominant inheritance |
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161 | (1) |
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Sex-linked dominant inheritance with male lethality |
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162 | (1) |
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Sex-linked dominant inheritance with unaffected males |
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163 | (1) |
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163 | (1) |
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164 | (1) |
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Uniparental disomy and imprinting |
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165 | (4) |
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169 | (1) |
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Germinal (gonadal) mosaicism |
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169 | (3) |
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172 | (1) |
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Mitochondrial inheritance |
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172 | (12) |
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175 | (9) |
| Appendix |
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184 | (34) |
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A1 Overlapping Normal distributions |
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184 | (2) |
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186 | (20) |
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A3 Length of prometaphase chromosome segments |
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206 | (12) |
| Index |
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218 | |
Other versions by this Author
