Oncofertility

by ;
Edition: 1st
Format: Hardcover
Pub. Date: 2007-10-15
Publisher(s): Springer Verlag
  • Free Shipping Icon

    This Item Qualifies for Free Shipping!*

    *Excludes marketplace orders.

List Price: $230.99

Rent Textbook

Select for Price
There was a problem. Please try again later.

Rent Digital

Rent Digital Options
Online:30 Days access
Downloadable:30 Days
$39.24
Online:60 Days access
Downloadable:60 Days
$52.32
Online:90 Days access
Downloadable:90 Days
$65.40
Online:120 Days access
Downloadable:120 Days
$78.48
Online:180 Days access
Downloadable:180 Days
$85.02
Online:1825 Days access
Downloadable:Lifetime Access
$130.80
$85.02

New Textbook

We're Sorry
Sold Out

Used Textbook

We're Sorry
Sold Out

How Marketplace Works:

  • This item is offered by an independent seller and not shipped from our warehouse
  • Item details like edition and cover design may differ from our description; see seller's comments before ordering.
  • Sellers much confirm and ship within two business days; otherwise, the order will be cancelled and refunded.
  • Marketplace purchases cannot be returned to eCampus.com. Contact the seller directly for inquiries; if no response within two days, contact customer service.
  • Additional shipping costs apply to Marketplace purchases. Review shipping costs at checkout.

Summary

While cancer survival rates have increased steadily over the last several decades, particularly among younger patients, the more aggressive forms of treatment that have made this possible often compromise a cancer patient's ability to later have biological children. In the past, pregnancy after cancer was largely unheard of. Today it is increasingly a possibility due to high survivorship rates in general and emerging reproductive technologies that give patients and their families options at the time of diagnosis to ensure a patient's future fertility (cryopreservation of ovarian tissue). Oncofertility has emerged as an interdisciplinary field bridging biomedical, social sciences and examines issues regarding an individual's fertility options, choice and goals in light of cancer diagnosis, treatment and survivorship. Written by leaders in this evolving field, the volume covers various aspects: medical, ethical and social.

Table of Contents

Forewordp. v
Forewordp. vii
Contributorsp. xvii
Introduction
The Emergence of a New Interdiscipline: Oncofertilityp. 3
Oncofertility: The New Offensive in the War on Cancerp. 3
Secondary Effects of Treatment on the Health and Quality of Life of Young Survivors of Cancerp. 4
Fertility Threats Due to Cancer Treatmentp. 5
An Emerging Urgent Unment Need for Young Cancer Patients: Balancing Life-Preserving but Fertility-Threatening Cancer Treatmentsp. 6
Information GAPp. 9
Data GAPp. 10
Option GAPp. 10
Conclusionp. 11
Fertility Risk and Treatment Options
Fertility Management for Women With Cancerp. 15
Ovarian Physiologyp. 15
Impact of Cancer Therapies on Ovarian Functionp. 18
Current Techniques of Fertility Preservationp. 20
Embryo Freezingp. 20
Ovarian Tissue Freezingp. 22
Oocyte Freezingp. 23
Future Directionsp. 25
Summaryp. 25
Referencesp. 26
Fertility Preservation in Adult Male Cancer Patientsp. 28
The Impact of Cancer on Male Reproductive Healthp. 28
Endocrine Effects of Tumorsp. 29
Cytotoxic Autoimmune Responsep. 30
Systemic Physiological Changesp. 31
Psychological Changes Associated with Cancerp. 31
The Impact of Cancer Treatment on Male Reproductive Healthp. 32
Effects of Radiation Therapyp. 32
Effects of Chemotherapyp. 36
Effects of Surgeryp. 38
Effects of Opiodsp. 39
Fertility Preservation in Male Cancer Patientsp. 39
American Society of Clinical Oncology Guidelinesp. 40
Sperm Cryopreservationp. 41
Overview of Sperm Collection Techniquesp. 42
Testicular Tissue Cryopreservation (ONCO-TESE)p. 42
Future Directions in Fertility Preservation in Male Cancer Patientsp. 45
Conclusionp. 45
Referencesp. 46
Managing Fertility in Childhood Cancer Patientsp. 50
Follow-up Guidelines Related to Male Fertilityp. 51
Risk Factorsp. 51
Surveillance and Screeningp. 51
Additional Management Issuesp. 52
Follow-up Guidelines Related to Female Fertilityp. 52
Risk Factorsp. 52
Surveillance and Screeningp. 53
Additional Management Issuesp. 54
Optimal Care for Pediatric Cancer Patientsp. 54
Referencesp. 55
Fertility Risk in Pediatric and Adolescent Cancersp. 57
Scope of the Problemp. 57
The Importance of Fertility to Cancer Patientsp. 57
Common Cancers in Children and their Treatmentp. 58
Fertility Risks for Young Femalesp. 58
Gonadotoxicity of Cancer Treatmentsp. 58
Chemotherapyp. 59
Radiationp. 59
Effects on the Hypothalamic-Pituitary-Ovarian Axisp. 61
Pregnancy Outcomes in Cancer Survivorsp. 63
Options for Preserving Fertility in Girls and Young Womenp. 63
Fertility Risks for Young Menp. 64
Chemotherapyp. 65
Radiotherapyp. 65
Options for Preserving Fertility in Boys and Young Menp. 66
Ethical Issues in Pediatric Patientsp. 67
Conclusionp. 67
Referencesp. 68
Oncofertility Techniques and Research
Bioengineering and the Ovarian Folliclep. 75
Follicle Growth In Vivop. 76
Culture Systems for Follicle Growthp. 77
Hydrogels for Three-Dimensional Culture In Vitrop. 78
Ovarian Transplantation Using Biomaterialsp. 79
Conclusionp. 80
Referencesp. 80
The Science of Cryobiologyp. 83
Introductionp. 83
Anatomy of Cryopreservationp. 83
The Effects of Water Precipitation (as Ice) During Coolingp. 84
Ice Nucleation, Crystallization, Vitrification, and Devitrificationp. 84
Solute Concentration as a Result of Ice Crystallization, The Associated Osmotic Effects, and Cell Death at Supra-Optimal Cooling Ratesp. 86
Cell Death at Sub-Optimal Cooling Rates and the Role of Cryoprotectants in Mitigating Cell Damagep. 90
Cryoprotectants: Beneficial Effectsp. 91
Cryoprotectants: Detrimental Effectsp. 94
Cell Death at Sub-Optimal Cooling Ratesp. 98
Cooling and Cooling Injury/Cold Shockp. 99
Vitrification as an Alternate to Equilibrium cryopreservationp. 102
Referencesp. 103
Ovarian Tissue Cryopreservation and Transplantation: Banking Reproductive Potential for the Futurep. 110
Indications for Ovarian Tissue Bankingp. 110
Scope of the Clinical Problem and Incidence of Ovarian Failurep. 110
Gonadotoxicity of Chemotherapyp. 111
Gonadotoxicity of Radiation Therapyp. 112
Limitations of Fertility: Preserving Techniquesp. 113
The Promise of Ovarian Tissue Bankingp. 115
Cryopreservation of Ovarian Tissue has been Successfulp. 116
Autotransplantation of Ovarian Tissue has been Successfulp. 117
Problems with Ovarian Transplantation: Re-Introduction of Cancerp. 123
Xenografting as a Potential Solutionp. 124
Conclusionp. 126
Referencesp. 126
Progress, History and Promise of Ovarian Cryopreservation and Transplantation for Pediatric Cancer Patientsp. 130
Referencesp. 132
Health Care Decision-Making
Oncofertility and the Social Sciencesp. 137
Studying Cancer Within the Social Sciencesp. 138
Gender and Oncofertilityp. 139
Gender and Patient-Physician Interactionsp. 140
Gender and the Experience of Infertilityp. 141
Race/Ethnicity and Oncofertilityp. 142
Race/Ethnicity and Patient-Physician Interactionsp. 143
Race/Ethnicity and Family and Community Involvementp. 144
The Digitial Divide and Race/Ethnicityp. 145
Conclusionp. 146
Referencesp. 147
Shared Decision Making: Fertility and Pediatric Cancersp. 149
The Current State of Pediatric Oncofertilityp. 150
Family Communication in Contextp. 151
Shared Decision Making in Theory and in Practicep. 152
Decision Making in Pediatrics and Cancerp. 152
Referencesp. 158
Ethical and Psychosocial Impact of Cancer-Related Infertility
Today's Research, Tomorrows Cures: The Ethical Implications of Oncofertilityp. 163
Expanding Options for Women - Follicle Preservation and Maturationp. 165
A Prairie Horizon: The Long View of Research on Fertilityp. 165
The Role of Oncologists and Infertility Specialistsp. 168
Ethical Issues in the Case of Childhood Cancersp. 170
The Special Case of Young Girlsp. 170
Research in Childrenp. 171
Assessing the Intervention: A Community Consent Process in Actionp. 173
The Ethical Implications for a New Terrain: Therapy or Enhancement?p. 174
Recalling a Complex Historyp. 176
Conclusionp. 178
Referencesp. 178
The Psychosocial Context of Cancer-Related Infertilityp. 180
The Social Contextp. 180
Psychosocial Screening for Infertility Concernsp. 183
Biopsychosocial Screening Instrument: How Can We Help You and Your Family?p. 183
Discussion and Implicationsp. 188
Referencesp. 190
Childhood Cancer: Fertility and Psychosocial Implicationsp. 191
Recent Research on Late Effects and Infertilityp. 191
Addressing the Threat of Infertilityp. 193
Childhood Cancer Survivors and Fertility Preservationp. 194
Male Infertilityp. 196
Access to Carep. 197
Conclusionp. 198
Referencesp. 198
Fertility Preservation and Adolescent Cancer Patients: Lessons from Adult Survivors of Childhood Cancer and Their Parentsp. 201
Methodsp. 203
Study Design and Sample Recruitmentp. 203
Data Collection and Analysisp. 203
Resultsp. 204
Sample Characteristicsp. 204
Content Analysisp. 204
Discussionp. 211
Conclusionp. 215
Referencesp. 216
Training in a New Medical Discipline and Medical Guidelines
Oncofertility: A New Medical Discipline and the Emerging Scholarp. 221
Infertility: An Unmet Clinical Need for Young Cancer Patientsp. 222
Oncofertility and the Oncofertility Scholarp. 226
Reproductive Endocrinology and Infertility as the Springboard to a New Oncofertility Scholarp. 226
Research Directionsp. 229
Future Directionsp. 230
Conclusionp. 231
Referencesp. 233
Oncofertility Consortium Consensus Statement: Guidelines for Ovarian Tissue Cryopreservationp. 235
Referencesp. 239
Patient Stories and Oncofertility
Personal Accounts of Cancer and Infertilityp. 243
A New Generation of Hope: Antoinette's Storyp. 243
Starting a Family One Day: Adriane's Storyp. 244
An Improvised Script: Beverley's Storyp. 245
Life is Worth Living: Brian's Storyp. 246
Young and Hopeful for the Future: Dorothy's Storyp. 246
Hope, from Texas to Panama: Elia's Storyp. 247
Oncofertility Optionsp. 249
Indexp. 257
Table of Contents provided by Ingram. All Rights Reserved.

An electronic version of this book is available through VitalSource.

This book is viewable on PC, Mac, iPhone, iPad, iPod Touch, and most smartphones.

By purchasing, you will be able to view this book online, as well as download it, for the chosen number of days.

Digital License

You are licensing a digital product for a set duration. Durations are set forth in the product description, with "Lifetime" typically meaning five (5) years of online access and permanent download to a supported device. All licenses are non-transferable.

More details can be found here.

A downloadable version of this book is available through the eCampus Reader or compatible Adobe readers.

Applications are available on iOS, Android, PC, Mac, and Windows Mobile platforms.

Please view the compatibility matrix prior to purchase.