
Oncofertility
by Woodruff, Teresa K.; Snyder, Karrie Ann, Ph.D.-
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Summary
Table of Contents
Foreword | p. v |
Foreword | p. vii |
Contributors | p. xvii |
Introduction | |
The Emergence of a New Interdiscipline: Oncofertility | p. 3 |
Oncofertility: The New Offensive in the War on Cancer | p. 3 |
Secondary Effects of Treatment on the Health and Quality of Life of Young Survivors of Cancer | p. 4 |
Fertility Threats Due to Cancer Treatment | p. 5 |
An Emerging Urgent Unment Need for Young Cancer Patients: Balancing Life-Preserving but Fertility-Threatening Cancer Treatments | p. 6 |
Information GAP | p. 9 |
Data GAP | p. 10 |
Option GAP | p. 10 |
Conclusion | p. 11 |
Fertility Risk and Treatment Options | |
Fertility Management for Women With Cancer | p. 15 |
Ovarian Physiology | p. 15 |
Impact of Cancer Therapies on Ovarian Function | p. 18 |
Current Techniques of Fertility Preservation | p. 20 |
Embryo Freezing | p. 20 |
Ovarian Tissue Freezing | p. 22 |
Oocyte Freezing | p. 23 |
Future Directions | p. 25 |
Summary | p. 25 |
References | p. 26 |
Fertility Preservation in Adult Male Cancer Patients | p. 28 |
The Impact of Cancer on Male Reproductive Health | p. 28 |
Endocrine Effects of Tumors | p. 29 |
Cytotoxic Autoimmune Response | p. 30 |
Systemic Physiological Changes | p. 31 |
Psychological Changes Associated with Cancer | p. 31 |
The Impact of Cancer Treatment on Male Reproductive Health | p. 32 |
Effects of Radiation Therapy | p. 32 |
Effects of Chemotherapy | p. 36 |
Effects of Surgery | p. 38 |
Effects of Opiods | p. 39 |
Fertility Preservation in Male Cancer Patients | p. 39 |
American Society of Clinical Oncology Guidelines | p. 40 |
Sperm Cryopreservation | p. 41 |
Overview of Sperm Collection Techniques | p. 42 |
Testicular Tissue Cryopreservation (ONCO-TESE) | p. 42 |
Future Directions in Fertility Preservation in Male Cancer Patients | p. 45 |
Conclusion | p. 45 |
References | p. 46 |
Managing Fertility in Childhood Cancer Patients | p. 50 |
Follow-up Guidelines Related to Male Fertility | p. 51 |
Risk Factors | p. 51 |
Surveillance and Screening | p. 51 |
Additional Management Issues | p. 52 |
Follow-up Guidelines Related to Female Fertility | p. 52 |
Risk Factors | p. 52 |
Surveillance and Screening | p. 53 |
Additional Management Issues | p. 54 |
Optimal Care for Pediatric Cancer Patients | p. 54 |
References | p. 55 |
Fertility Risk in Pediatric and Adolescent Cancers | p. 57 |
Scope of the Problem | p. 57 |
The Importance of Fertility to Cancer Patients | p. 57 |
Common Cancers in Children and their Treatment | p. 58 |
Fertility Risks for Young Females | p. 58 |
Gonadotoxicity of Cancer Treatments | p. 58 |
Chemotherapy | p. 59 |
Radiation | p. 59 |
Effects on the Hypothalamic-Pituitary-Ovarian Axis | p. 61 |
Pregnancy Outcomes in Cancer Survivors | p. 63 |
Options for Preserving Fertility in Girls and Young Women | p. 63 |
Fertility Risks for Young Men | p. 64 |
Chemotherapy | p. 65 |
Radiotherapy | p. 65 |
Options for Preserving Fertility in Boys and Young Men | p. 66 |
Ethical Issues in Pediatric Patients | p. 67 |
Conclusion | p. 67 |
References | p. 68 |
Oncofertility Techniques and Research | |
Bioengineering and the Ovarian Follicle | p. 75 |
Follicle Growth In Vivo | p. 76 |
Culture Systems for Follicle Growth | p. 77 |
Hydrogels for Three-Dimensional Culture In Vitro | p. 78 |
Ovarian Transplantation Using Biomaterials | p. 79 |
Conclusion | p. 80 |
References | p. 80 |
The Science of Cryobiology | p. 83 |
Introduction | p. 83 |
Anatomy of Cryopreservation | p. 83 |
The Effects of Water Precipitation (as Ice) During Cooling | p. 84 |
Ice Nucleation, Crystallization, Vitrification, and Devitrification | p. 84 |
Solute Concentration as a Result of Ice Crystallization, The Associated Osmotic Effects, and Cell Death at Supra-Optimal Cooling Rates | p. 86 |
Cell Death at Sub-Optimal Cooling Rates and the Role of Cryoprotectants in Mitigating Cell Damage | p. 90 |
Cryoprotectants: Beneficial Effects | p. 91 |
Cryoprotectants: Detrimental Effects | p. 94 |
Cell Death at Sub-Optimal Cooling Rates | p. 98 |
Cooling and Cooling Injury/Cold Shock | p. 99 |
Vitrification as an Alternate to Equilibrium cryopreservation | p. 102 |
References | p. 103 |
Ovarian Tissue Cryopreservation and Transplantation: Banking Reproductive Potential for the Future | p. 110 |
Indications for Ovarian Tissue Banking | p. 110 |
Scope of the Clinical Problem and Incidence of Ovarian Failure | p. 110 |
Gonadotoxicity of Chemotherapy | p. 111 |
Gonadotoxicity of Radiation Therapy | p. 112 |
Limitations of Fertility: Preserving Techniques | p. 113 |
The Promise of Ovarian Tissue Banking | p. 115 |
Cryopreservation of Ovarian Tissue has been Successful | p. 116 |
Autotransplantation of Ovarian Tissue has been Successful | p. 117 |
Problems with Ovarian Transplantation: Re-Introduction of Cancer | p. 123 |
Xenografting as a Potential Solution | p. 124 |
Conclusion | p. 126 |
References | p. 126 |
Progress, History and Promise of Ovarian Cryopreservation and Transplantation for Pediatric Cancer Patients | p. 130 |
References | p. 132 |
Health Care Decision-Making | |
Oncofertility and the Social Sciences | p. 137 |
Studying Cancer Within the Social Sciences | p. 138 |
Gender and Oncofertility | p. 139 |
Gender and Patient-Physician Interactions | p. 140 |
Gender and the Experience of Infertility | p. 141 |
Race/Ethnicity and Oncofertility | p. 142 |
Race/Ethnicity and Patient-Physician Interactions | p. 143 |
Race/Ethnicity and Family and Community Involvement | p. 144 |
The Digitial Divide and Race/Ethnicity | p. 145 |
Conclusion | p. 146 |
References | p. 147 |
Shared Decision Making: Fertility and Pediatric Cancers | p. 149 |
The Current State of Pediatric Oncofertility | p. 150 |
Family Communication in Context | p. 151 |
Shared Decision Making in Theory and in Practice | p. 152 |
Decision Making in Pediatrics and Cancer | p. 152 |
References | p. 158 |
Ethical and Psychosocial Impact of Cancer-Related Infertility | |
Today's Research, Tomorrows Cures: The Ethical Implications of Oncofertility | p. 163 |
Expanding Options for Women - Follicle Preservation and Maturation | p. 165 |
A Prairie Horizon: The Long View of Research on Fertility | p. 165 |
The Role of Oncologists and Infertility Specialists | p. 168 |
Ethical Issues in the Case of Childhood Cancers | p. 170 |
The Special Case of Young Girls | p. 170 |
Research in Children | p. 171 |
Assessing the Intervention: A Community Consent Process in Action | p. 173 |
The Ethical Implications for a New Terrain: Therapy or Enhancement? | p. 174 |
Recalling a Complex History | p. 176 |
Conclusion | p. 178 |
References | p. 178 |
The Psychosocial Context of Cancer-Related Infertility | p. 180 |
The Social Context | p. 180 |
Psychosocial Screening for Infertility Concerns | p. 183 |
Biopsychosocial Screening Instrument: How Can We Help You and Your Family? | p. 183 |
Discussion and Implications | p. 188 |
References | p. 190 |
Childhood Cancer: Fertility and Psychosocial Implications | p. 191 |
Recent Research on Late Effects and Infertility | p. 191 |
Addressing the Threat of Infertility | p. 193 |
Childhood Cancer Survivors and Fertility Preservation | p. 194 |
Male Infertility | p. 196 |
Access to Care | p. 197 |
Conclusion | p. 198 |
References | p. 198 |
Fertility Preservation and Adolescent Cancer Patients: Lessons from Adult Survivors of Childhood Cancer and Their Parents | p. 201 |
Methods | p. 203 |
Study Design and Sample Recruitment | p. 203 |
Data Collection and Analysis | p. 203 |
Results | p. 204 |
Sample Characteristics | p. 204 |
Content Analysis | p. 204 |
Discussion | p. 211 |
Conclusion | p. 215 |
References | p. 216 |
Training in a New Medical Discipline and Medical Guidelines | |
Oncofertility: A New Medical Discipline and the Emerging Scholar | p. 221 |
Infertility: An Unmet Clinical Need for Young Cancer Patients | p. 222 |
Oncofertility and the Oncofertility Scholar | p. 226 |
Reproductive Endocrinology and Infertility as the Springboard to a New Oncofertility Scholar | p. 226 |
Research Directions | p. 229 |
Future Directions | p. 230 |
Conclusion | p. 231 |
References | p. 233 |
Oncofertility Consortium Consensus Statement: Guidelines for Ovarian Tissue Cryopreservation | p. 235 |
References | p. 239 |
Patient Stories and Oncofertility | |
Personal Accounts of Cancer and Infertility | p. 243 |
A New Generation of Hope: Antoinette's Story | p. 243 |
Starting a Family One Day: Adriane's Story | p. 244 |
An Improvised Script: Beverley's Story | p. 245 |
Life is Worth Living: Brian's Story | p. 246 |
Young and Hopeful for the Future: Dorothy's Story | p. 246 |
Hope, from Texas to Panama: Elia's Story | p. 247 |
Oncofertility Options | p. 249 |
Index | p. 257 |
Table of Contents provided by Ingram. All Rights Reserved. |
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