Principles and Practice of Fertility Preservation

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Edition: 1st
Format: Hardcover
Pub. Date: 2011-03-14
Publisher(s): Cambridge University Press
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Summary

The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.

Table of Contents

Foreword
Preface
Introduction
The evolution of ART
The effect of chemotherapy and radiotherapy treatment for cancer on the reproductive system in humans
Fertility preservation in non-cancer patients
Cancer Biology, Epidemiology and Treatment
Basic cancer biology and immunology
Breast cancer and fertility preservation: a view from oncology
Breast cancer therapy and reproduction
Pediatric cancer therapy and fertility
Cancer epidemiology and environmental factors in children, adolescents and young adults
Reproductive Biology and Cryobiology
Life and death in the germ line: apoptosis and the origins of DNA damage in human spermatozoa
Molecular aspects of follicular development
Fundamental cryobiology of reproductive cells and tissues: concepts and misconceptions
Fundamental aspects of vitrification as a method of reproductive cell, tissue, and organ cryopreservation
Fertility Preservation Strategies in the Male
Hormonal suppression for fertility preservation in the male
Cryopreservation of spermatozoa: old routine and new perspectives
Transplantation of cryopreserved spermatogonia
Fertility preservation strategies in males: cryopreservation and transplantation of testicular tissue
Assisted reproductive techniques and donor sperm in cancer patients
Fertility Preservation Strategies in the Female: Medical/Surgical
Use of GnRH agonists for prevention of chemotherapy-induced gonado-toxicity
Ovarian transposition
Fertility-saving surgery for cervical cancer
Results of conservative management of ovarian malignant tumors
Fertility Preservation Stategies in the Female: ART
Embryo cryopreservation as a fertility preservation strategy
Oocyte cryopreservation - slow freezing
Cryopreservation of human oocytes and the evolution of vitrification technology for this purpose
Cryopreservation and transplantation of isolated follicles
ART and oocyte donation in cancer survivors
Ovarian Cryopreservation and Transplantation
General overview of ovarian cryobanking
Ovarian tissue cryopreservation
Ovarian tissue transplantation
Whole ovary freezing
Ovarian transplantation: whole ovary transplantation
In-Vitro Follicle Growth and Maturation
Molecular and cellular integrity of cultured follicles
In-vitro growth (IVG) systems for human oocytes: from primordial to maturation
Contributions of ovarian stromal cells to follicle culture
In-vitro maturation of GV oocytes
Clinical potential of in-vitro maturation
Future Technologies
From pluripotent stem cells to germ cells
Artificial ovary
Predicting ovarian futures: the contribution of genetics
Ethical, Legal and Religious Issues with Fertility Preservation
Psychological issues of cancer survivors
Fertility preservation: ethical considerations
Legal aspects of fertility preservation
Christian ethics in fertility preservation
Index
Table of Contents provided by Publisher. All Rights Reserved.

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