| Color Plates |
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xxv | |
| Bert La Du - ASPET Plenary Lecture |
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Bert N. La Du, a Summary of His Career to 1998 |
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1 | (2) |
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Diversity and Processing of Acetylcholinesterase |
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3 | (22) |
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| Irwin B. Wilson Plenary Lecture |
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Structural and Functional Studies on Acetylcholinesterase: A Perspective |
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25 | (10) |
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| I. THE GENES AND GENE PRODUCTS OF THE CHOLINESTERASES |
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| A. Lectures |
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Genetic Manipulations of Catalytic and Non-Catalytic Functions of Human Cholinesterases |
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35 | (6) |
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ACHE Knockout Mouse; Cat AChE and Cat BChE Sequences; Tetramers of BChE |
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41 | (4) |
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Molecular Mechanisms Controlling the Synapse-Specific Expression and Activity-Linked Regulation of Acetylcholinesterase in Skeletal Muscle Fibers |
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45 | (6) |
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Celine Boudreau-Lariviere |
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Intronic Elements Appear Essential for the Differentiation-Specific Expression of Acetylcholinesterase in C2C12 Myotubes |
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51 | (6) |
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The Building of Acetylcholinesterase Collagen-Tailed Forms: A Model |
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57 | (8) |
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Fluorescent Fasciculin: A New Probe for Studying the Targeting, Attachment, and Organization of Acetylcholinesterase at the Neuromuscular Synapse |
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65 | (6) |
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Factors That Determine AChE Efficacy in Synaptic Function |
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71 | (8) |
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Glucocorticoid Control of Acetylcholinesterase and Butyrylcholinesterase Expression in the Mammalian Organism |
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79 | (8) |
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Four Acetylcholinesterase Genes in the Nematodes Caenorhabditis elegans and Caenorhabditis briggsae |
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87 | (6) |
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Neural Activation of Muscles Regulates Muscle Acetylcholinesterase Expression |
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93 | (6) |
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Acetylcholinesterase in Elapid Snakes: Identification of a New Exon in Bungarus fasciatus |
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99 | (6) |
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Structure and Function of Cholinesterases from Agnathans and Cephalochordates: Implications for the Evolution of Cholinesterases |
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105 | (6) |
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| B. Posters |
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The Human ACHE Locus Includes a Polymorphic Enhancer Domain 17KB Upstream from the Transcription Start Site |
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111 | (1) |
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Novel Transcription Start Site for Murine AChE |
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112 | (1) |
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Neurotrophins Differentially Regulate Expression of Cholinergic Enzymes in Cultured Spinal Cord Motoneurons |
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113 | (2) |
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Extrajunctional Expression of the Asymmetric Molecular Forms of Acetylcholinesterase in Slow Rat Muscles Transinnervated by a Fast Motor Nerve |
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115 | (2) |
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Increased Expression of Acetylcholinesterase T and R Transcripts during Hematopoietic Differentiation Is Accompanied by Parallel Elevations in the Levels of Their Respective Molecular Forms |
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117 | (2) |
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Expression of the Acetylcholinesterase Gene in Skeletal Muscle Fibers: Role of Intronic Sequences |
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119 | (2) |
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Celine Boudreau-Lariviere |
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Intronic Sequences Influence Pre-mRNA Splicing of Acetylcholinesterase during Muscle Differentiation |
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121 | (2) |
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Calcineurin Enhances mRNA Stability of Acetylcholinesterase during Muscle Differentiation in C2-C12 Cells |
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123 | (2) |
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Degradation of AChE mRNA in the Normal and Denervated Rat Skeletal Muscle |
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125 | (2) |
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Transcriptional Control of Acetylcholinesterase Expression during Quail Muscle Development in Culture |
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127 | (1) |
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Activity-Linked Regulation of Acetylcholinesterase mRNA Levels Involves Distinct Molecular Mechanisms in Developing versus Adult Skeletal Muscles |
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128 | (2) |
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Celine Boudreau-Lariviere |
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Testosterone Regulation of Acetylcholinesterase in the Rat Levator Ani Muscle |
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130 | (2) |
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Assembly, Stability and Secretion of Acetylcholinesterase in Cultured Mouse Muscle Cells |
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132 | (2) |
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Regulation of Acetylcholinesterase Oligomerization in the Muscles by Associated-Acetylcholinesterase Collagen, ColQ |
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134 | (1) |
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The Glycolipid-Addition Signal of Acetylcholinesterase: Cellular Compartmentation, Cleavage, GPI Addition and Secretion |
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135 | (1) |
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Four Acetylcholinesterase Genes in the Nematode Caenorhabditis elegans. I. Ace-1 and Ace-2 |
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136 | (2) |
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Marta Grauso Rita Romani Yann Fedon |
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Four Acetylcholinesterase Genes in the Nematode Caenorhabditis elegans. II: The Third and Fourth Ace Genes |
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138 | (2) |
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CDNA Cloning, in Vitro Expression, and Biochemical Characterization of Cholinesterase 1 and Cholinesterase 2 from Amphioxus: Comparison with Cholinesterase 1 and Cholinesterase 2 Produced in Vivo |
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140 | (1) |
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Acetylcholinesterase Expression during Development of Danio rerio |
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141 | (2) |
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Molecular Cloning and Characterization of a cDNA Encoding AChE from Optic Lobe of Loligo opalescences |
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143 | (1) |
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Electrophorus electricus Acetylcholinesterase: Gene and Protein Structure |
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144 | (1) |
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Amino Acid Sequence of Horse Serum Butyrylcholinesterase |
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145 | (2) |
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Acetylcholinesterase and Butyrylcholinesterase of Cat |
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147 | (1) |
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Amanda K. Miller-Lindholm |
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Bovine Acetylcholinestrase-Cloning, Expression and Characterization of the Recombinant Enzyme |
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148 | (1) |
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Acetylcholinesterase Autoimmunity in Vitro |
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149 | (1) |
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Expression of Human Butyrylcholinesterase in Trichoplusia ni Insect Larvae |
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150 | (1) |
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Stabilization of Recombinant Drosophila Acetylcholinesterase |
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151 | (2) |
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| II. CHOLINESTERASES IN THERAPY OF ALZHEIMER'S DISEASE |
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| A. Lectures |
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Pharmacological Basis of Cholinergic Therapy in Alzheimer Disease |
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153 | (6) |
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Age Influences the Synergy between Butyrylcholinesterase K Variant and Apolipoprotein E 4 in Late-Onset Alzheimer's Disease |
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159 | (8) |
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Molecular Interactions of Acetylcholinesterase with the Synaptic Basal Lamina and the Senile Plaques |
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167 | (8) |
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Expression and Glycosylation of Acetylcholinesterase in Alzheimer's Disease Brain: From Pathogenesis to Diagnosis |
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175 | (6) |
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| B. Posters |
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Comparative Effects of Cholinesterase Inhibitors on Glutamate-Induced Neuronal Cell Death |
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181 | (1) |
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Acetylcholinesterase Enhances the Neurotoxicity of β-Amyloid Fibrils |
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182 | (1) |
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Multilevel Approaches to AChE-Induced Impairments in Learning and Memory |
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183 | (2) |
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Identification of an Acetylcholinesterase Fragment That Promotes Alzheimer β-Amyloid Fibril Formation |
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185 | (2) |
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Differential Effect of Acetylcholinesterase on Neuronal and Glial Cells in Culture |
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187 | (2) |
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| III. MECHANISTIC CONSIDERATIONS OF CHOLINESTERASE CATALYSIS AND INHIBITION |
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| A. Lectures |
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Substrate Binding to the Peripheral Site Occurs on the Catalytic Pathway of Acetylcholinesterase and Leads to Substrate Inhibition |
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189 | (8) |
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Structure of the Acylation Transition State for Acetylcholinesterase Catalysis |
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197 | (6) |
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Contribution of the Active Center Functional Architecture to AChe Reactivity Toward Substrates and Inhibitors |
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203 | (8) |
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The Effect of Peripheral Site Ligands on the Reaction Kinetics of Phosphyl and Carboxyl Esters with Acetylcholinesterase |
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211 | (4) |
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Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands |
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215 | (8) |
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Reaction of Human Butyrylcholinesterase (BChE) H117 Enzymes with Carbamates |
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223 | (4) |
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| B. Posters |
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An Integrated Model for the Molecular Traffic Through the Active Site of Cholinesterases |
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227 | (2) |
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Substrate Binding to the Acetylcholinesterase Peripheral Site Promotes Substrate Hydrolysis but also Gives Rise to Substrate Inhibition |
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229 | (1) |
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Activity of Torpedo californica Acetylcholinesterase in the Crystalline State |
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230 | (2) |
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Correlation of Isotope and Viscosity Effects: A Measure of Rate Determination for the Acylation Stage of Acetylcholinesterase Catalysis |
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232 | (1) |
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Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Enzymes |
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233 | (1) |
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Does Electrostatic Attraction or Steering by Charged Residues within the Gorge Contribute to the Reactivity of AChE? |
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234 | (2) |
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Photoaffinity Labeling with [3H]-DDF Reveals TRP82 and TYR332 Are Involved in Two Quaternary Ammonium Binding Domains of Human Butyrylcholinesterase |
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236 | (2) |
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4-Aminoquinolines as AChE Inhibitors: Studies into Species Selectivity |
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238 | (1) |
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Identification of Residues Involved in Naja naja oxiana AChE Insensitivity to Fasciculin |
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239 | (1) |
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Expression and Purification of Recombinant Mutants of Fasciculin from Mammalian Cells |
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240 | (2) |
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Photo-Induced Inhibition of Human Butyrylcholinesterase by Phenyldiazonium Esters |
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242 | (1) |
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Inhibition of Acetylcholinesterase (AChE; E.C. 3.1.1.7) and Butyrylcholinesterase (BChE; E.C. 3.1.1.8) by Terbutaline |
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243 | (1) |
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Effects of Triton X100 on the Activity of Acetylcholinesterases from Drosophila melanogaster, Musca domestica and Torpedo californica |
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244 | (1) |
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Cyclic, Selectively Permeable Acetylcholinesterase Inhibitors: Design and Screening of Peptide and Pseudopeptide Compounds |
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245 | (1) |
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The Aromatic Moiety at Position-86 of HuAChE Accelerate the Aging of Phosphonyl-AChE Conjugates Through Cation- Interactions |
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246 | (1) |
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pH Dependence of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants: Further Evidence for a Push-Pull Mechanism |
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247 | (2) |
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ESMS as a Unique Tool for the Molecular Monitoring of Reactions between HuAChE and Various OP-Agents |
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249 | (1) |
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Reactivation of Enantiomeric Organophosphonyl Conjugates of Acetylcholinesterase Mutants F295L and F297I by Mono- and Bis-Quaternary Oximes |
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250 | (2) |
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Improved Acetylcholinesterase Reactivation with Bis-Oximes Modeled on Crystal Structure |
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252 | (1) |
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Caged Cholinergic Ligands and Photoregulation of Cholinesterase Activities |
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253 | (2) |
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| IV. NERVE AGENTS AND ANTIDOTES |
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| A. Lectures |
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Current Capabilities in Extrapolating from Animal to Human the Capacity of Human Butyrylcholinesterase to Detoxify Organophosphates |
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255 | (6) |
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Retrospective Detection of Exposure to Nerve Agents in the Rhesus Monkey and in Man |
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261 | (8) |
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Acetylcholinesterase, a Versatile Protein: Applied Toxicology Aspects |
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269 | (8) |
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Quaternary-Lipophilic Carbamates with Blood Brain Barrier Permeability as Potential Drugs for the Treatment of Diseases Associated with Cholinergic Deficiency |
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277 | (6) |
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The Role of Oligosaccharides in the Pharmacokinetics of Cholinesterases |
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283 | (8) |
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Contribution of Primary Sequence and Post-Translation Modification to the Pharmacokinetics of Human and Bovine Acetylcholinesterases |
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291 | (8) |
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| B. Posters |
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Synthesis of Imidazolio-Quinuclidinium Oximes: Potential Antidotes against Organophosphorus Poisoning |
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299 | (1) |
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A Comparison of Blood Cholinesterase Activities, Pyridostigmine Inhibition of Red Cell Acetylcholinesterase, and Butyrylcholinesterase Phenotypes in Gulf War Veterans and Normal Controls |
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300 | (2) |
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Blood Cholinesterase Activity Levels of Victims Intoxicated with Sarin in Matsumoto and Tokyo Subway System |
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302 | (1) |
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Diisopropylphosphorofluoridate-Induced Modulation of Different Nerve Action Potentials: Involvement of Decreased Cholinesterase Activity |
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303 | (2) |
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Sequestration of Toxic Phosphorylated Oximes by Stoichiometric and Catalytic Scavengers |
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305 | (2) |
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Characterization of ChEs Immobilized on Polyurethane Foams |
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307 | (2) |
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| V. CHOLINESTERASES AND RELATED PROTEINS: COMPUTATION AND CRYSTALLOGRAPHY |
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| A. Lectures |
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Structure-Function Relationships in High Molecular Weight PAF-Acetylhydrolases from the Studies of a Microbial α/β Hydrolase |
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309 | (6) |
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Crystal Structure of Mouse Acetylcholinesterase |
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315 | (8) |
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3D Structure at 2.7A Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II |
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323 | (4) |
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Computer Simulation Studies of Acetylcholinesterase Dynamics and Activity |
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327 | (4) |
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Fasciculin Inhibition of Mouse Acetylcholinesterase: Crystal Structure of the Complex and Mutagenesis |
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331 | (8) |
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The Push-Pull Mechanism of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants: Broad pH Profiles and Molecular Dynamics Calculations |
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339 | (6) |
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Thermodynamic Correlation with Kinetic Association Rates for Several Mutants of Mouse Acetylcholinesterase |
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345 | (6) |
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Quaternary Structure of Tetrameric Acetylcholinesterase |
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351 | (6) |
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Fast Molecular Docking Methods |
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357 | (10) |
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| B. Posters |
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|
Weighted-Ensemble Brownian Dynamics for Charged Ligand Diffusion onto Acetylcholinesterase |
|
|
367 | (1) |
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Alternate Pathways for Acetic Acid and Acetate Ion Release from Acetylcholinesterase: A Molecular Dynamics Study |
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368 | (1) |
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Molecular Dynamics of Acetylcholinesterase Dimer |
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369 | (1) |
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3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7A Resolution |
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370 | (1) |
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Crystal Structures of Complexes of E2020-Related Compounds with Torpedo californica Acetylcholinesterase |
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371 | (1) |
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Alternative Crystal Forms of Torpedo californica Acetylcholinesterase |
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372 | (1) |
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Kinetic and X-Ray Crystallographic Studies of the Binding of Ena-713 to Torpedo californica Acetylcholinesterase |
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373 | (2) |
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|
Compatibility of Structures Inferred from Mutagenesis and from X-Ray Crystallography for Various AChE Complexes |
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375 | (2) |
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Oxime Reactivation of Acetylcholinesterase Inhibited by Enantiomeric Organophosphates: A Computational Analysis |
|
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377 | (2) |
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| VI. CHOLINESTERASES AND RELATED PROTEINS: STRUCTURAL AND FUNCTIONAL CONSIDERATIONS |
|
| A. Lectures |
|
|
Site-Directed Photo-Probes for Structural and Functional Investigations on Cholinesterases |
|
|
379 | (8) |
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|
Comparison of Cholinesterases and Carboxylesterase as Bioscavengers for Organophosphorus Compounds |
|
|
387 | (6) |
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Optimization of the Signal Peptide for Glycosyl Phosphatidylinositol-(GPI)-Modification of Human Acetylcholinesterase |
|
|
393 | (6) |
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|
Mechanical Aspects of the Phosphotriesterase Activity of Human Butyrylcholinesterase G117H Mutant |
|
|
399 | (8) |
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|
Metal Binding Motifs in Cholinesterases and Neuroligins: Structural Comparison |
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407 | (6) |
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|
A View from the Gorge: Reactivation and the Importance of Water |
|
|
413 | (6) |
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|
Structural Changes in the Active Site Gorge of Phosphylated Cholinesterase Accompanying the Aging Process |
|
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419 | (6) |
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|
Crystal Structures of ``Aged'' Phosphorylated and Phosphonylated Torpedo californica Acetylcholinesterase |
|
|
425 | (8) |
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| B. Posters |
|
|
On the Mechanisms of Anticholinesterase Action of Organophosphorus Inhibitors (OPI): Accessibility of Phosphorus Atom for Interaction with Various Cholinesterases (ChE) |
|
|
433 | (1) |
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|
Mechanical Aspects of the Phosphotriesterase Activity of Human Butyrylcholinesterase G117H Mutant |
|
|
434 | (1) |
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|
Surface Residues Near the Peripheral Site Affect the Stability of Torpedo Acetylcholinesterase |
|
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435 | (1) |
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|
Stability of the Quaternary Structure of Butyrylcholinesterase Subjected to Ultrasound or Hydrostatic Pressure |
|
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436 | (2) |
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Membrane-Promoted Unfolding of Torpedo californica and Bungarus fasciatus Acetylcholinesterase |
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438 | (2) |
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Association of Tetramers of Human Butyrylcholinesterase Is Mediated by Conserved Aromatic Residues of the Carboxy Terminus |
|
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440 | (2) |
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Assembly of Acetylcholinesterase Subunits in Vitro |
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442 | (2) |
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The Heparin-Binding Sites in the Collagenic Tail of Acetylcholinesterase: I. Importance of the Triple-Helical Conformation |
|
|
444 | (2) |
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The Heparin-Binding Sites in the Collagenic Tail of Acetylcholinesterase: II. Site-Directed Mutagenesis Approach |
|
|
446 | (2) |
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|
The Conjunction of a Conserved Electrostatic Motif and a Common Cholinesterase Fold Defines a Class of Adhesion Proteins |
|
|
448 | (2) |
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|
Expression and Tissue Distribution of Cholinesterases via EST Analysis |
|
|
450 | (1) |
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|
Homology Modelling of Drosophila melanogaster and Electrophorus Eel Acetylcholinesterases |
|
|
451 | (1) |
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Acetylcholinesterase Structural Perturbations Examined through Cysteine Substitution Mutagenesis |
|
|
452 | (1) |
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|
Structural Modifications of the Ω Loop in Human Acetylcholinesterase |
|
|
453 | (1) |
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|
Crystal Structures of ``Aged'' Phosphorylated and Phosphonylated Torpedo californica Acetylcholinesterase |
|
|
454 | (3) |
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| VII. CHOLINESTERASE DATABASES, WORKSHOP ON STRUCTURE-FUNCTION |
|
| A. Lectures |
|
|
A Database of Pairwise Aligned 3-D Structures for the Acetylcholinesterases, Lipases and Other Homologous Proteins |
|
|
457 | (6) |
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|
Esther 1998, aChEdb Short Tutorial |
|
|
463 | (6) |
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|
3D Structure of a Complex of the Anti-Alzheimer Drug, E2020, with Acetylcholinesterase at 2.5A Resolution |
|
|
469 | (8) |
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|
| VIII. ACETYLCHOLINESTERASES IN AGRICULTURAL USE, INSECTICIDES AND RESISTANCE |
|
| A. Lectures |
|
|
The OECD Program: Biological Resource Management for Sustainable Agricultural Systems: An Introduction to the Session: Cholinesterase Inhibitors in Agricultural Use. Pesticides |
|
|
477 | (2) |
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|
Researches on Cholinesterases and Plant Protection: An Introduction |
|
|
479 | (4) |
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|
|
Acetylcholinesterase and Insecticide Resistance in the Mosquito Culex pipiens: A Review |
|
|
483 | (8) |
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|
Biochemical and Molecular Characterisation of Insecticide Insensitive Acetylcholinesterase in Resistant Insects |
|
|
491 | (6) |
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|
Molecular Basis of Esterase-Mediated Op Resistance in Two Higher Diptera |
|
|
497 | (6) |
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Acetylcholinesterase Increase in Drosophila as a Mechanism of Resistance to Insecticide |
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503 | (6) |
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Why Do Some Parasitic Nematodes Secrete Acetylcholinesterase (AChE)? |
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509 | (6) |
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Secretory Acetylcholinesterases from the Nematode Parasite Nippostrongylus brasiliensis: Properties and Implications for Mucosal Immunity |
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515 | (8) |
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Differential Plant-Parasitic Nematode Sensitivity to Acetylcholinesterase Inhibitors |
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523 | (8) |
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Isomalathion Stereoisomers: Insecticide Impurities or New Probe of Cholinesterase? |
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531 | (8) |
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Cholinesterases and Agriculture: Humans, Laboratory Animals, Wildlife |
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539 | (8) |
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| B. Posters |
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Purification and Biochemical Characterization of Affinity-Tagged Musca domestica Acetylcholinesterase Secreted from Baculovirus Infected Cells |
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547 | (1) |
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Mutations in the Housefly Acetylcholinesterase Gene That Confer Resistance to Insecticides |
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548 | (1) |
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An Insensitive AChE Confers Insecticide Resistance in Myzus persicae |
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549 | (1) |
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The Acetylcholinesterase Gene and Organophosphorous Resistance in the Australian Sheep Blowfly, Lucilia cuprina |
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550 | (3) |
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Shielding of Acetylcholinesterase Does Not Result in the Protection of Honey Bee Against Poisoning by Organophosphates |
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Engineering Sensitive Acetylcholinesterase for Detection of Organophosphate and Carbamate Insecticides |
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553 | (1) |
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Comparison of Fetal and Maternal Brain Cholinesterase Activity Following Repeated versus Single Late Gestational Exposure to Chlorpyrifos |
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554 | (3) |
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| IX. NON-CHOLINERGIC FUNCTIONS OF CHOLINESTERASES AND GENETIC ABNORMALITIES IN THE CHOLINESTERASES |
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| A. Lectures |
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Non-Cholinergic Actions of Acetylcholinesterase in the Substantia Nigra |
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557 | (6) |
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Possible Adhesive Function of Transiently Expressed Acetylcholinesterase in Developing Cerebral Cortex |
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563 | (6) |
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Nonenzymatic Roles of Cholinesterases in Avian Neurogenesis: Antisense-BChE Transfection Increases AChE Expression, Differentiation and Apoptosis in Retinal Reaggregates |
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569 | (8) |
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A Morphogenic Role for Acetylcholinesterase in Neurite Outgrowth: Studies on a Cell Adhesive Function |
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577 | (8) |
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Pharmacologic Tests of a Role for Acetylcholinesterase in Promoting Neurite Outgrowth by Dorsal Root Ganglia |
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585 | (6) |
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| B. Posters |
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Suppression of Butyrylcholinesterase Induces Overexpression of Acetylcholinesterase and Increased Apoptosis in Embryonic Chick Retinospheroids |
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591 | (2) |
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The Role of Acetylcholinesterase in Neuronal Differentiation |
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593 | (1) |
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Cholinesterase Activities in Intact Human Pulmonary Vessels Treated with LTD4 |
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594 | (2) |
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Increase of Cholinesterase Activity in Intact Human Bronchial Preparations Treated with Indomethacin |
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596 | (2) |
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Studies on a Molecular Form (C4/5) of Human Butyrylcholinesterase (BChE) |
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598 | (2) |
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E. A. Chautard-Freire-Maia |
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Frequency of the F2 Mutation of Human Butyrylcholinesterase in a Random Population Samples from Southern Brazil |
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|
600 | (1) |
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E. A. Chautard-Freire-Maia |
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Frequencies of the Butyrylcholinesterase K Mutation in Southern Brazilian Population Samples of European and African Origin |
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601 | (2) |
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E. A. Chautard-Freire-Maia |
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The Relation of Nutrition Index (Ni) with the C4/5 Molecular Form of Butyrylcholinesterase (BChE) in Human Adults |
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603 | (2) |
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Eleidi A. Chautard-Freire-Maia |
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| Participants |
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605 | (14) |
| Author Index |
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619 | (4) |
| Index |
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623 | |
Other versions by this Author
