Contributors |
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vii | |
Preface |
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xi | |
Introduction |
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Global Burden of Tuberculosis: Past, Present, and Future |
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3 | (12) |
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Clinical and Epidemiological Perspectives |
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Overview of Clinical Tuberculosis |
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15 | (18) |
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Molecular Epidemiology of Mycobacterium tuberculosis |
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33 | (16) |
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Clinical Mycobacteriology (Tuberculosis) Laboratory: Services and Methods |
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49 | (22) |
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71 | (14) |
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Molecular Diagnosis of Mycobacterial Infections |
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85 | (16) |
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Current Therapies and Drug Resistance |
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Global Impact of Multidrug Resistance |
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101 | (14) |
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Mechanisms of Drug Resistance in Mycobacterium tuberculosis |
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115 | (28) |
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THE ORGANISM MYCOBACTERIUM TUBERCULOSIS |
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Introduction to Functional Genomics of the Mycobacterium tuberculosis Complex |
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143 | (12) |
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Comparative Genomics and Evolution of Mycobacterium bovis BCG |
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155 | (10) |
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TB or Not TB: a Structural Genomics Mission? |
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165 | (18) |
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183 | (8) |
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Repetitive DNA in the Mycobacterium tuberculosis Complex |
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191 | (12) |
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Mycobacteriophages and Tuberculosis |
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203 | (16) |
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Control of Mycobacterial Transcription |
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219 | (16) |
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The Proteome of Mycobacterium tuberculosis |
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235 | (26) |
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The Cell Envelope of Mycobacterium tuberculosis with Special Reference to the Capsule and Outer Permeability Barrier |
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261 | (14) |
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Structure, Biosynthesis, and Genetics of the Mycolic Acid-Arabinogalactan-Peptidoglycan Complex |
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275 | (12) |
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A Waxy Tale, by Mycobacterium tuberculosis |
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287 | (22) |
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General Metabolism and Biochemical Pathways of Tubercle Bacilli |
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309 | (32) |
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Iron Metabolism in the Tubercle Bacillus and Other Mycobacteria |
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341 | (18) |
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Two-Component Systems, Protein Kinases, and Signal Transduction in Mycobacterium tuberculosis |
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359 | (10) |
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369 | (10) |
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379 | (26) |
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HOST-PATHOGEN INTERACTIONS |
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Phagocytic Uptake and Intracellular Survival |
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Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells |
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405 | (22) |
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Mycobacterium tuberculosis: the Indigestible Microbe |
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427 | (10) |
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Intracellular Models of Mycobacterium tuberculosis Infection |
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437 | (14) |
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Dendritic Cells in Host Immunity to Mycobacterium tuberculosis |
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451 | (14) |
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Host Immune Responses and Antigenic Variation |
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CD8 T Cells in Tuberculosis |
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465 | (10) |
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475 | (14) |
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Th1 and Th2 Cytokines in the Human Immune Response to Tuberculosis |
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489 | (8) |
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Ramakrishna Vankayalapati |
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Role of Antibody-Mediated Immunity in Host Defense against Mycobacterium tuberculosis |
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497 | (16) |
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The PE and PPE Multigene Families of Mycobacteria |
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513 | (16) |
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Mycobacterium marinarum and Fish and Frog Models of Infection |
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529 | (8) |
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Experimental Infection Models of Tuberculosis in Domestic and Wild Animals |
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537 | (10) |
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Animal Models of Tuberculosis |
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547 | (14) |
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Tuberculosis Vaccine Preclinical Screening and Development |
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561 | (12) |
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Index |
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573 | |